Dr. rer. nat. Stefan Höhme

Dr. rer. nat. Stefan Höhme

PROJECT LEADER

Image analysis and multiscale tissue modeling

hoehme@uni-leipzig.de

+49 (0) 341 - 97 16660

Room: 447

ACADEMIC CAREER

  • Interdisciplinary Centre for Bioinformatics (IZBI), Group Image analysis and multiscale tissue modeling (have a look at: www.hoehme.com)
  • Faculty for Bioinformatics, Leipzig University
  • Max Planck Institute for Human Cognitive and Brain Science (MPI CBS)
  • Max Planck Institute for Mathematics in the Sciences (MPI MIS)
  • Institute for Medical Informatics, Statistics and Epidemiology (IMISE)
  • Interdisciplinary Centre for Bioinformatics (IZBI)

SCIENTIFIC INTERESTS

  • Image / Volume processing and analysis
  • Visualisation
  • Multiscale liver models

MISCELLANEOUS

Awards & Grants
  • Reinhard Heinrich Doctoral Thesis Award 2011 (1st prize) by the European Society for Mathematical and Theoretical Biology (ESMTB) for best annual thesis from any area of Mathematical and Theoretical Biology
  • Grant: DFG Emmy-Noether-Programme (2015-2020)
  • Grant: BMBF LiSyM (Liver Systems Medicine) (2015-2021)
  • Grant: BMBF LiSyM-Krebs (2021-2024)

PUBLICATIONS

https://hoehmelab.izbi.uni-leipzig.de/index.php/publications.html

2022 (1)

  • Christian H. Holland, Ricardo O. Ramirez Flores, Maiju Myllys, Reham Hassan, Karolina Edlund, Ute Hofmann, Rosemarie Marchan, Cristina Cadenas, Jörg Reinders, Stefan Hoehme, Abdel-latif Seddek, Steven Dooley, Verena Keitel, Patricio Godoy, Brigitte Begher-Tibbe, Christian Trautwein, Christian Rupp, Sebastian Mueller, Thomas Longerich, Jan G. Hengstler, Julio Saez-Rodriguez, Ahmed Ghallab. Transcriptomic Cross-Species Analysis of Chronic Liver Disease Reveals Consistent Regulation Between Humans and Mice. Hepatology Communications. 2022. 6: 161-177.

2021 (3)

  • A. Ghallab, R. Hassan, M. Myllys, W. Albrecht, A. Friebel, S. Hoehme, U. Hofmann, A. L. Seddek, A. Braeuning, L. Kuepfer, B. Cramer, H. U. Humpf, P. Boor, G. H. Degen, J. G. Hengstler. Subcellular spatio-temporal intravital kinetics of aflatoxin B(1) and ochratoxin A in liver and kidney. Arch Toxicol. 2021. 95: 2163-2177.
  • Ahmed Ghallab, Maiju Myllys, Adrian Friebel, Julia Duda, Karolina Edlund, Emina Halilbasic, Mihael Vucur, Zaynab Hobloss, Lisa Brackhagen, Brigitte Begher-Tibbe, Reham Hassan, Michael Burke, Erhan Genc, Lynn Johann Frohwein, Ute Hofmann, Christian H. Holland, Daniela González, Magdalena Keller, Abdel-latif Seddek, Tahany Abbas, Elsayed S. I. Mohammed, Andreas Teufel, Timo Itzel, Sarah Metzler, Rosemarie Marchan, Cristina Cadenas, Carsten Watzl, Michael A. Nitsche, Franziska Kappenberg, Tom Luedde, Thomas Longerich, Jörg Rahnenführer, Stefan Hoehme, Michael Trauner, Jan G. Hengstler. Spatio-Temporal Multiscale Analysis of Western Diet-Fed Mice Reveals a Translationally Relevant Sequence of Events during NAFLD Progression. Cells. 2021. 10: 2516.
  • N. Vartak, G. Guenther, F. Joly, A. Damle-Vartak, G. Wibbelt, J. Fickel, S. Jörs, B. Begher-Tibbe, A. Friebel, K. Wansing, A. Ghallab, M. Rosselin, N. Boissier, I. Vignon-Clementel, C. Hedberg, F. Geisler, H. Hofer, P. Jansen, S. Hoehme, D. Drasdo, J. G. Hengstler. Intravital Dynamic and Correlative Imaging of Mouse Livers Reveals Diffusion-Dominated Canalicular and Flow-Augmented Ductular Bile Flux. Hepatology. 2021. 73: 1531-1550.

2017 (1)

  • S. Hoehme, A. Friebel, S. Hammad, D. Drasdo, J. G. Hengstler. Creation of Three-Dimensional Liver Tissue Models from Experimental Images for Systems Medicine. Methods Mol Biol. 2017. 1506: 319-362.

2016 (1)

  • A. Ghallab, G. Celliere, S. G. Henkel, D. Driesch, S. Hoehme, U. Hofmann, S. Zellmer, P. Godoy, A. Sachinidis, M. Blaszkewicz, R. Reif, R. Marchan, L. Kuepfer, D. Haussinger, D. Drasdo, R. Gebhardt, J. G. Hengstler. Model-guided identification of a therapeutic strategy to reduce hyperammonemia in liver diseases. J Hepatol. 2016. 64: 860-71.