Mechanism-based Multiscale Model to Dissect the Tipping Point from Liver Cirrhosis to Hepatocellular Carcinoma
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PROJECT DESCRIPTION
Liver cancer, particularly hepatocellular carcinoma (HCC), will rise sharply over the next ten years due to the obesity pandemic and the increase in metabolic dysfunction-associated steatotic liver disease (MASLD). Already 30% of the world’s population is affected, and MASLD can lead to steatohepatitis (MASH), liver cirrhosis and HCC. It is striking that a third of MASLD-associated HCC develops in non-cirrhotic tissue and is often discovered late.
In Germany, around 10,000 people develop MASLD-related HCC every year, often preventable through early detection. Men have a higher risk, but the causes are unclear. Strategies for early detection and assessment of liver regeneration in MASLD patients are crucial to enable curative surgery, reduce mortality and reduce the need for transplants.
In the C-TIP-HCC project, systems medicine approaches and technologies are used to improve clinical patient care by means of mechanistic 3D modeling, e.g. by constructing more accurate diagnostic scores.
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Project Leader Dr. Höhme, IZBI
Scientific Assistant Dr. Höhme, Adrian Friebel, Deng Zhipeng, Marlene Mertens
Duration 01.07.2024 – 30.06.2027
Extern Project Website https://www.hoehme.com/
Funding third-party funding