Dipl. inf. Adrian Friebel

ACADEMIC CAREER

• Interdisciplinary Centre for Bioinformatics (IZBI), University Leipzig, Group: Image analysis and multiscale tissue modeling (hoemeLab Research Group, since 2017), (Drasdo AG, 2011 - 2017)
• ScaDS.AI (Center for Scalable Data Analytics and Artificial Intelligence) Dresden/Leipzig (HoehmeLab Associate Member)
• SIKT (Sächsische Inkubator für Klinische Translation) (HoehmeLab Associate Member)
• Faculty for Bioinformatics, Leipzig University, since 2016

 

SCIENTIFIC INTERESTS

MAIN TOPICS

• Machine learning based interactive biomedical image segmentation
• Deep learning based biomedical image processing
• Biomedical image quantification
• Data visualization

 

PUBLICATIONS

2023 (2)

• R. J. P. Custodio, Z. Hobloss, M. Myllys, R. Hassan, D. González, J. Reinders, J. Bornhorst, A. K. Weishaupt, A. L. Seddek, T. Abbas, A. Friebel, S. Hoehme, S. Getzmann, J. G. Hengstler, C. van Thriel, A. Ghallab. Cognitive Functions, Neurotransmitter Alterations, and Hippocampal Microstructural Changes in Mice Caused by Feeding on Western Diet. Cells. 2023. 12:
• A. Ghallab, D. González, E. Strängberg, U. Hofmann, M. Myllys, R. Hassan, Z. Hobloss, L. Brackhagen, B. Begher-Tibbe, J. C. Duda, C. Drenda, F. Kappenberg, J. Reinders, A. Friebel, M. Vucur, M. Turajski, A. L. Seddek, T. Abbas, N. Abdelmageed, S. A. F. Morad, W. Morad, A. Hamdy, W. Albrecht, N. Kittana, M. Assali, N. Vartak, C. van Thriel, A. Sous, P. Nell, M. Villar-Fernandez, C. Cadenas, E. Genc, R. Marchan, T. Luedde, P. Åkerblad, J. Mattsson, H. U. Marschall, S. Hoehme, G. Stirnimann, M. Schwab, P. Boor, K. Amann, J. Schmitz, J. H. Bräsen, J. Rahnenführer, K. Edlund, S. J. Karpen, B. Simbrunner, T. Reiberger, M. Mandorfer, M. Trauner, P. A. Dawson, E. Lindström, J. G. Hengstler. Inhibition of the renal apical sodium dependent bile acid transporter prevents cholemic nephropathy in mice with obstructive cholestasis. J Hepatol. 2023. 80: 268-281.

2022 (5)

• A. Friebel, T. Johann, D. Drasdo, S. Hoehme. Guided interactive image segmentation using machine learning and color-based image set clustering. Bioinformatics. 2022. 38: 4622-4628.
• A. Ghallab, R. Hassan, U. Hofmann, A. Friebel, Z. Hobloss, L. Brackhagen, B. Begher-Tibbe, M. Myllys, J. Reinders, N. Overbeck, S. Sezgin, S. Zühlke, A. L. Seddek, W. Murad, T. Brecklinghaus, F. Kappenberg, J. Rahnenführer, D. González, C. Goldring, I. M. Copple, R. Marchan, T. Longerich, M. Vucur, T. Luedde, S. Urban, A. Canbay, T. Schreiter, M. Trauner, J. Y. Akakpo, M. Olyaee, S. C. Curry, J. P. Sowa, H. Jaeschke, S. Hoehme, J. G. Hengstler. Interruption of bile acid uptake by hepatocytes after acetaminophen overdose ameliorates hepatotoxicity. J Hepatol. 2022. 77: 71-83.
• R. Hassan, A. Friebel, L. Brackhagen, Z. Hobloss, M. Myllys, D. González, W. Albrecht, E. S. I. Mohammed, A. L. Seddek, R. Marchan, C. Cadenas, B. Cramer, H. U. Humpf, L. Hartl, B. Simbrunner, T. Reiberger, M. Trauner, S. Hoehme, G. H. Degen, J. G. Hengstler, A. Ghallab. Hypoalbuminemia affects the spatio-temporal tissue distribution of ochratoxin A in liver and kidneys: consequences for organ toxicity. Arch Toxicol. 2022. 96: 2967-2981.
• R. Hassan, D. González, Z. Hobloss, L. Brackhagen, M. Myllys, A. Friebel, A. L. Seddek, R. Marchan, B. Cramer, H. U. Humpf, S. Hoehme, G. H. Degen, J. G. Hengstler, A. Ghallab. Inhibition of cytochrome P450 enhances the nephro- and hepatotoxicity of ochratoxin A. Arch Toxicol. 2022. 96: 3349-3361.
• R. Hassan, M. Myllys, L. Brackhagen, Z. Hobloss, D. González, A. L. Seddek, A. Friebel, S. Hoehme, R. Marchan, M. Trauner, J. G. Hengstler, A. Ghallab. Colchicine overdose impairs the capacity of Kupffer cells to clear foreign particles and endotoxins. Arch Toxicol. 2022. 96: 3067-3076.

2021 (3)

• A. Ghallab, R. Hassan, M. Myllys, W. Albrecht, A. Friebel, S. Hoehme, U. Hofmann, A. L. Seddek, A. Braeuning, L. Kuepfer, B. Cramer, H. U. Humpf, P. Boor, G. H. Degen, J. G. Hengstler. Subcellular spatio-temporal intravital kinetics of aflatoxin B(1) and ochratoxin A in liver and kidney. Arch Toxicol. 2021. 95: 2163-2177.
• Ahmed Ghallab, Maiju Myllys, Adrian Friebel, Julia Duda, Karolina Edlund, Emina Halilbasic, Mihael Vucur, Zaynab Hobloss, Lisa Brackhagen, Brigitte Begher-Tibbe, Reham Hassan, Michael Burke, Erhan Genc, Lynn Johann Frohwein, Ute Hofmann, Christian H. Holland, Daniela González, Magdalena Keller, Abdel-latif Seddek, Tahany Abbas, Elsayed S. I. Mohammed, Andreas Teufel, Timo Itzel, Sarah Metzler, Rosemarie Marchan, Cristina Cadenas, Carsten Watzl, Michael A. Nitsche, Franziska Kappenberg, Tom Luedde, Thomas Longerich, Jörg Rahnenführer, Stefan Hoehme, Michael Trauner, Jan G. Hengstler. Spatio-Temporal Multiscale Analysis of Western Diet-Fed Mice Reveals a Translationally Relevant Sequence of Events during NAFLD Progression. Cells. 2021. 10: 2516.
• N. Vartak, G. Guenther, F. Joly, A. Damle-Vartak, G. Wibbelt, J. Fickel, S. Jörs, B. Begher-Tibbe, A. Friebel, K. Wansing, A. Ghallab, M. Rosselin, N. Boissier, I. Vignon-Clementel, C. Hedberg, F. Geisler, H. Hofer, P. Jansen, S. Hoehme, D. Drasdo, J. G. Hengstler. Intravital Dynamic and Correlative Imaging of Mouse Livers Reveals Diffusion-Dominated Canalicular and Flow-Augmented Ductular Bile Flux. Hepatology. 2021. 73: 1531-1550.

2018 (2)

• P. O. Bucur, M. Bekheit, C. Audebert, A. Othman, S. Hammad, M. Sebagh, M. A. Allard, B. Decante, A. Friebel, E. Miquelestorena-Standley, D. Drasdo, J. G. Hengstler, I. E. Vignon-Clementel, E. Vibert. Modulating Portal Hemodynamics With Vascular Ring Allows Efficient Regeneration After Partial Hepatectomy in a Porcine Model. Ann Surg. 2018. 268: 134-142.
• G. Peeters, C. Debbaut, A. Friebel, P. Cornillie, W. H. De Vos, K. Favere, I. Vander Elst, T. Vandecasteele, T. Johann, L. Van Hoorebeke, D. Monbaliu, D. Drasdo, S. Hoehme, W. Laleman, P. Segers. Quantitative analysis of hepatic macro- and microvascular alterations during cirrhogenesis in the rat. J Anat. 2018. 232: 485-496.

2017 (2)

• S. Hoehme, A. Friebel, S. Hammad, D. Drasdo, J. G. Hengstler. Creation of Three-Dimensional Liver Tissue Models from Experimental Images for Systems Medicine. Methods Mol Biol. 2017. 1506: 319-362.
• Peeters G, Debbaut C, Laleman W, Friebel A, Monbaliu D, Vander Elst I, Detrez JR, Vandecasteele T, De Schryver T, Van Hoorebeke L, Favere K, Verbeke J, Segers P, Cornillie P, De Vos WH. Corrigendum - A multilevel framework to reconstruct anatomical 3D models of the hepatic vasculature in rat livers. J Anat. 2017. 231: 786.

2015 (1)

• A. Friebel, J. Neitsch, T. Johann, S. Hammad, J. G. Hengstler, D. Drasdo, S. Höhme. TiQuant: software for tissue analysis, quantification and surface reconstruction. Bioinformatics. 2015. 31: 3234-6.

2014 (1)

• S. Hammad, S. Höhme, A. Friebel, I. von Recklinghausen, A. Othman, B. Begher-Tibbe, R. Reif, P. Godoy, T. Johann, A. Vartak, K. Golka, P. O. Bucur, E. Vibert, R. Marchan, B. Christ, S. Dooley, C. Meyer, I. Ilkavets, U. Dahmen, O. Dirsch, J. Bottger, R. Gebhardt, D. Drasdo, J. G. Hengstler. Protocols for staining of bile canalicular and sinusoidal networks of human, mouse and pig livers, three-dimensional reconstruction and quantification of tissue microarchitecture by image processing and analysis. Arch Toxicol. 2014. 88: 1161-83.

 

MISCELLANEOUS