Dr. rer. nat. Torsten Thalheim

Dr. rer. nat. Torsten Thalheim

POSTDOC

Tissue Organisation

thalheim@izbi.uni-leipzig.de

+49 (0) 341 - 97 16675

Room: 442

ACADEMIC CAREER

  • 2000 - 2007: Study, Computer Science (University of Leipzig), Diploma Thesis: Hybride Ameisenalgorithmen zur Lösung von Proteinfaltungsproblemen
  • 2007 - 2011 Study, Applied Natural Science (TU Freiberg) and Helmholtz Centre for Environmental Research, Ph.D. thesis: Tautomere chemischer Strukturen
  • 2011 - 2014 PostDoc, Leibniz Institute for Age Research - Fritz Lipmann Institut
  • since 2014 IZBI

SCIENTIFIC INTERESTS

  • data science
  • agent based modeling
  • graph theory

PUBLICATIONS

2022 (2)

  • Ali Hageb, Torsten Thalheim, Kalpana J Nattamai, Bettina Möhrle, Mehmet Saçma, Vadim Sakk, Lars Thielecke, Kerstin Cornils, Carolin Grandy, Fabian Port, Kay-E Gottschalk, Jan-Philipp Mallm, Ingmar Glauche, Jörg Galle, Medhanie A Mulaw, Hartmut Geiger. Reduced adhesion of aged intestinal stem cells contributes to an accelerated clonal drift. Life Science Alliance. 2022. 5: e202201408.
  • André Scherag, Wahram Andrikyan, Tobias Dreischulte, Pauline Dürr, Martin F. Fromm, Jan Gewehr, Ulrich Jaehde, Miriam Kesselmeier, Renke Maas, Petra A. Thürmann, Frank Meineke, Daniel Neumann, Julia Palm, Thomas Peschel, Editha Räuscher, Susann Schulze, Torsten Thalheim, Thomas Wendt, Markus Loeffler, D. Ammon, W. Andrikyan, U. Bartz, B. Bergh, T. Bertsche, O. Beyan, S. Biergans, H. Binder, M. Boeker, H. Bogatsch, R. Böhm, A. Böhmer, J. Brandes, C. Bulin, D. Caliskan, I. Cascorbi, M. Coenen, F. Dietz, F. Dörje, T. Dreischulte, J. Drepper, P. Dürr, A. Dürschmid, F. Eckelt, R. Eils, A. Eisert, C. Engel, F. Erdfelder, K. Farker, M. Federbusch, S. Franke, N. Freier, T. Frese, M. Fromm, K. Fünfgeld, T. Ganslandt, J. Gewehr, D. Grigutsch, W. Haefeli, U. Hahn, A. Härdtlein, R. Harnisch, S. Härterich, M. Hartmann, R. Häuslschmid, C. Haverkamp, O. Heinze, P. Horki, M. Hug, T. Iskra, U. Jaehde, S. Jäger, P. Jürs, C. Jüttner, J. Kaftan, T. Kaiser, K. Karsten Dafonte, M. Kesselmeier, S. Kiefer, S. Klasing, O. Kohlbacher, D. Kraska, S. Krause, S. Kreutzke, R. Krock, K. Kuhn, S. Lederer, M. Lehne, M. Löbe, M. Loeffler, C. Lohr, V. Lowitsch, N. Lüneburg, M. Lüönd, I. Lutz, R. Maas, U. Mansmann, K. Marquardt, A. Medek, F. Meineke, A. Merzweiler, others. POLAR – „POLypharmazie, Arzneimittelwechselwirkungen und Risiken“ – wie können Daten aus der stationären Krankenversorgung zur Beurteilung beitragen?. Prävention und Gesundheitsförderung. 2022.

2021 (2)

  • Felix Hofmann, Torsten Thalheim, Karen Rother, Marianne Quaas, Christiane Kerner, Jens Przybilla, Gabriela Aust, Joerg Galle. How to Obtain a Mega-Intestine with Normal Morphology: In Silico Modelling of Postnatal Intestinal Growth in a Cd97-Transgenic Mouse. International Journal of Molecular Sciences. 2021. 22: 7345.
  • T. Thalheim, S. Siebert, M. Quaas, M. Herberg, M. R. Schweiger, G. Aust, J. Galle. Epigenetic Drifts during Long-Term Intestinal Organoid Culture. Cells. 2021. 10: 1718.

2020 (1)

  • T. Thalheim, L. Hopp, M. Herberg, S. Siebert, C. Kerner, M. Quaas, M. R. Schweiger, G. Aust, J. Galle. Fighting Against Promoter DNA Hyper-Methylation: Protective Histone Modification Profiles of Stress-Resistant Intestinal Stem Cells. Int J Mol Sci. 2020. 21:

2019 (1)

  • M. Herberg, S. Siebert, M. Quaas, T. Thalheim, K. Rother, M. Hussong, J. Altmuller, C. Kerner, J. Galle, M. R. Schweiger, G. Aust. Loss of Msh2 and a single-radiation hit induce common, genome-wide, and persistent epigenetic changes in the intestine. Clin Epigenetics. 2019. 11: 019-0639.

2018 (4)

  • Y. A. Miroshnikova, H. Q. Le, D. Schneider, T. Thalheim, M. Rubsam, N. Bremicker, J. Polleux, N. Kamprad, M. Tarantola, I. Wang, M. Balland, C. M. Niessen, J. Galle, S. A. Wickstrom. Adhesion forces and cortical tension couple cell proliferation and differentiation to drive epidermal stratification. Nat Cell Biol. 2018. 20: 69-80.
  • T. Thalheim, M. Herberg, J. Galle. Linking DNA Damage and Age-Related Promoter DNA Hyper-Methylation in the Intestine. In: Genes 2018.
  • T. Thalheim, L. Hopp, H. Binder, G. Aust, J. Galle. On the Cooperation between Epigenetics and Transcription Factor Networks in the Specification of Tissue Stem Cells. Epigenomes. 2018. 2: 20.
  • T. Thalheim, M. Quaas, M. Herberg, U. D. Braumann, C. Kerner, M. Loeffler, G. Aust, J. Galle. Linking stem cell function and growth pattern of intestinal organoids. Dev Biol. 2018. 433: 254-261.

2017 (1)

  • T. Thalheim, M. Herberg, M. Loeffler, J. Galle. The Regulatory Capacity of Bivalent Genes-A Theoretical Approach. Int J Mol Sci. 2017. 18:

2016 (1)

  • T. Thalheim, P. Buske, J. Przybilla, K. Rother, M. Loeffler, J. Galle. Stem cell competition in the gut: insights from multi-scale computational modelling. J R Soc Interface. 2016. 13:

2015 (1)

  • Torsten Thalheim, Barbara Wagner, Ralph Kühne, Martin Middendorf, Gerrit Schüürmann. A Branch-and-Bound Approach for Tautomer Enumeration. Molecular Informatics. 2015. 34: 263-275.

2014 (1)

  • Rolf Hühne, Torsten Thalheim, Jürgen Sühnel. AgeFactDB--the JenAge Ageing Factor Database--towards data integration in ageing research. Nucleic Acids Res. 2014. 42: D892--D896.

2010 (2)

  • Torsten Thalheim, Armin Vollmer, Ralf-Uwe Ebert, Ralph Kühne, Gerrit Schüürmann. Tautomer identification and tautomer structure generation based on the InChI code. J Chem Inf Model. 2010. 50: 1223--1232.
  • Torsten Thalheim. Tautomererzeugung basierend auf Inchi-String. Nachrichten aus der Chemie. 2010. 58: 1253--1255.

2008 (1)

  • Torsten Thalheim, Daniel Merkle, Martin Middendorf. Protein Folding in the HP-Model Solved With a Hybrid Population Based ACO Algorithm. IAENG International Journal of Computer Science. 2008. 35: 291-300.