Dr. rer. nat. Torsten Thalheim

Dr. rer. nat. Torsten Thalheim


Tissue Organisation


+49 (0) 341 - 97 16675

Room: 442


  • 2000 - 2007: Study, Computer Science (University of Leipzig), Diploma Thesis: Hybride Ameisenalgorithmen zur Lösung von Proteinfaltungsproblemen
  • 2007 - 2011 Study, Applied Natural Science (TU Freiberg) and Helmholtz Centre for Environmental Research, Ph.D. thesis: Tautomere chemischer Strukturen
  • 2011 - 2014 PostDoc, Leibniz Institute for Age Research - Fritz Lipmann Institut
  • since 2014 IZBI


  • data science
  • agent based modeling
  • graph theory


2021 (2)

  • Felix Hofmann, Torsten Thalheim, Karen Rother, Marianne Quaas, Christiane Kerner, Jens Przybilla, Gabriela Aust, Joerg Galle. How to Obtain a Mega-Intestine with Normal Morphology: In Silico Modelling of Postnatal Intestinal Growth in a Cd97-Transgenic Mouse. International Journal of Molecular Sciences. 2021. 22: 7345.
  • T. Thalheim, S. Siebert, M. Quaas, M. Herberg, M. R. Schweiger, G. Aust, J. Galle. Epigenetic Drifts during Long-Term Intestinal Organoid Culture. Cells. 2021. 10: 1718.

2020 (1)

  • T. Thalheim, L. Hopp, M. Herberg, S. Siebert, C. Kerner, M. Quaas, M. R. Schweiger, G. Aust, J. Galle. Fighting Against Promoter DNA Hyper-Methylation: Protective Histone Modification Profiles of Stress-Resistant Intestinal Stem Cells. Int J Mol Sci. 2020. 21:

2019 (1)

  • M. Herberg, S. Siebert, M. Quaas, T. Thalheim, K. Rother, M. Hussong, J. Altmuller, C. Kerner, J. Galle, M. R. Schweiger, G. Aust. Loss of Msh2 and a single-radiation hit induce common, genome-wide, and persistent epigenetic changes in the intestine. Clin Epigenetics. 2019. 11: 019-0639.

2018 (4)

  • Y. A. Miroshnikova, H. Q. Le, D. Schneider, T. Thalheim, M. Rubsam, N. Bremicker, J. Polleux, N. Kamprad, M. Tarantola, I. Wang, M. Balland, C. M. Niessen, J. Galle, S. A. Wickstrom. Adhesion forces and cortical tension couple cell proliferation and differentiation to drive epidermal stratification. Nat Cell Biol. 2018. 20: 69-80.
  • T. Thalheim, M. Herberg, J. Galle. Linking DNA Damage and Age-Related Promoter DNA Hyper-Methylation in the Intestine. In: Genes 2018.
  • T. Thalheim, L. Hopp, H. Binder, G. Aust, J. Galle. On the Cooperation between Epigenetics and Transcription Factor Networks in the Specification of Tissue Stem Cells. Epigenomes. 2018. 2: 20.
  • T. Thalheim, M. Quaas, M. Herberg, U. D. Braumann, C. Kerner, M. Loeffler, G. Aust, J. Galle. Linking stem cell function and growth pattern of intestinal organoids. Dev Biol. 2018. 433: 254-261.

2017 (1)

  • T. Thalheim, M. Herberg, M. Loeffler, J. Galle. The Regulatory Capacity of Bivalent Genes-A Theoretical Approach. Int J Mol Sci. 2017. 18:

2016 (1)

  • T. Thalheim, P. Buske, J. Przybilla, K. Rother, M. Loeffler, J. Galle. Stem cell competition in the gut: insights from multi-scale computational modelling. J R Soc Interface. 2016. 13:

2015 (1)

  • Torsten Thalheim, Barbara Wagner, Ralph Kühne, Martin Middendorf, Gerrit Schüürmann. A Branch-and-Bound Approach for Tautomer Enumeration. Molecular Informatics. 2015. 34: 263-275.

2014 (1)

  • Rolf Hühne, Torsten Thalheim, Jürgen Sühnel. AgeFactDB--the JenAge Ageing Factor Database--towards data integration in ageing research. Nucleic Acids Res. 2014. 42: D892--D896.

2010 (2)

  • Torsten Thalheim, Armin Vollmer, Ralf-Uwe Ebert, Ralph Kühne, Gerrit Schüürmann. Tautomer identification and tautomer structure generation based on the InChI code. J Chem Inf Model. 2010. 50: 1223--1232.
  • Torsten Thalheim. Tautomererzeugung basierend auf Inchi-String. Nachrichten aus der Chemie. 2010. 58: 1253--1255.

2008 (1)

  • Torsten Thalheim, Daniel Merkle, Martin Middendorf. Protein Folding in the HP-Model Solved With a Hybrid Population Based ACO Algorithm. IAENG International Journal of Computer Science. 2008. 35: 291-300.