Dr. rer. nat. Lena Sünke Mortensen

ACADEMIC CAREER

• 2006 BSc in Biology, Westfälische-Wilhelms-Universität Münster
• 2007 - 2012 International Max Planck Research School in Neurosciences, Georg-August-Universität Göttingen
• 2012 PhD (Dr. rer. nat.) in the dept. Molecular Biology of Neuronal Signals, Max Planck Institute of Experimental Medicine, Title "Modulation of synaptic transmissioin by the voltage gated potassium channel Eag1"
• 2013 visiting postdoctoral scientist in Joshua Singer's group at the University of Maryland, USA (5 months)
• 2012 - 2018 Postdoctoral Researcher in the dept Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Topic: Molecular mechanisms of vesicle release in the mammalian retina
• 2018 - 2019 MSc in Bioinformatics, Leipzig University
• 2020 - 2022 IZBI, Leipzig University

SCIENTIFIC INTERESTS

• Data mining and integration of high throughput OMICs data
• Epidemiology of health and disease
• Neurophysiology

PUBLICATIONS

2023 (1)

• M. Helm, M. Schmidt, E. Del Duca, Y. Liu, L. S. Mortensen, J. Loui, Y. Zheng, H. Binder, E. Guttman-Yassky, G. Cotsarelis, J. C. Simon, R. A. Ferrer. Repurposing DPP4-Inhibition to Improve Hair Follicle Activation and Regeneration. J Invest Dermatol. 2023.

2021 (3)

• Hans Binder, Maria Schmidt, Henry Loeffler-Wirth, Lena Suenke Mortensen, Manfred Kunz. Melanoma Single-Cell Biology in Experimental and Clinical Settings. Journal of Clinical Medicine. 2021. 10: 506.
• Maria Schmidt, Lena Sünke Mortensen, Henry Loeffler-Wirth, Corinna Kosnopfel, Knut Krohn, Hans Binder, Manfred Kunz. Single-cell trajectories of melanoma cell resistance to targeted treatment. Cancer biology & medicine. 2021.
• M. Schmidt, L. S. Mortensen, H. Loeffler-Wirth, C. Kosnopfel, K. Krohn, H. Binder, M. Kunz. Single-cell trajectories of melanoma cell resistance to targeted treatment. Cancer Biol Med. 2021. 19: 56-73.

MISCELLANEOUS

Publications outside of IZBI-work:

• Mortensen LS, Park SJH, Ke, JB, Cooper BH, Zhang L, Imig, C, Löwel, S, Reim K, Brose N, Demb J, Rhee JS, Singer JH. Complexin 3 increases the fidelity of signalling in a retinal circuit by regulating exocytosis at ribbon synapses. Cell Reports 2016, DOI: http://dx.doi.org/10.1016/j.celrep.2016.05.012
• Mortensen LS, Schmidt H, Farsi Z, Barrantes-Freer A, Ufartes R, Eilers J, Sakaba T, Stühmer W, Pardo LA. KV10.1 opposes activity-dependent increase in Ca2+-influx into the presynaptic terminal of the parallel fibre – Purkinje cell synapse. J Physiol 2015; 593(1); 181-196
• Barrantes-Freer A, Kim E, Bielanska J, Giese A, Mortensen LS, Stühmer W, Pardo LA. Functional properties of the plasma membrane of human glioma initiating cells. J Neuropathol Exp Neurol 2013; 72(4):307-3024
• Ufartes Mas R, Schneider T, Mortensen LS, de Juan Romero C, Heintrich K, Knötgen H, Beilinson V, Möbius W, Tarabykin V, Alves, F, Pardo LA, Rawlins N, Stühmer W. Kv10.1 (Eag1) reactivity to antipsychotic/antidepressant drugs. Hum Mol Genet 2013; 22(11):2247-2262
• Baune BT, Hohoff C, Mortensen LS, Deckert J, Arolt V, Domschke K. Serotonin transporter polymorphism (5-HTTLPR) association with melancholic depression: a female specific effect? Depress Anxiety 2008;25(11):920-5
• Domschke K, Hohoff C, Mortensen LS, Roehrs T, Deckert J, Arolt V, Baune BT. Monoamine oxidase A variant influences antidepressant treatment response in female patients with Major Depression. Prog Neuropsychopharmacol Biol Psychiatry 2008 Jan 1;32(1):224-8
• Kersting A, Kroker K, Horstmann J, Baune BT, Hohoff C, Mortensen LS, Neumann LC, Arolt V, Domschke K. Association of MAO-A variant with complicated grief in major depression. Neuropsychobiology 2007; 56(4):191-6