Prof. Dr. med. Markus Löffler

Prof. Dr. med. Markus Löffler


+49 (0) 341 - 97 16100

Room: IMISE - Institut für Medizinische Informatik, Statistik und Epidemiologie


  • since 2023 Senior Project Leader
  • since 2009 Scientific Director of the LIFE Research Center for Civilization Diseases​ (LIFE), University of Leipzig
  • since 2001 Scientific Director of the Interdisciplinary Center for Bioinformatics (IZBI), University of Leipzig
  • since 1999 Scientific Director of the Center of Clinical Trials Leipzig (ZKS), University of Leipzig
  • since 1994 Full Professor and Director of the Institute of Medical Informatics, Statistics and Epidemiology (IMISE), University of Leipzig
  • 1984 – 1994 Research group leader Biometry, University of Köln
  • 1980 – 1984 Res​​earch assistant Biometry, University of Köln
  • 1993 Sabbatical Leave, Dept. Statistics, University Reading, England
  • 1990 Habilitation und Venia Legendi in Medical Documentation, Statistics and Biomathematics, University of Köln
  • 1983 Dissertation Dr. med., University of Köln
  • 1982 Diploma in Physics, University of Köln
  • 1980 Approbation to practise medicine, University of Köln
  • 1976 – 82 Study of Physics at University of Köln
  • 1974 – 80 Study of Medicine at Universtiy of Köln


  • Biometrics and data management for a large number of clinical trials, biomarker cohort studies and epidemiological studies within 10 national research networks.
  • Member of steering committees of these networks (glioma, lymphoma, colorectal cancer, breast cancer, sepsis, heart failure)
  • Editorial board member of various academic journals
  • Biometry of interventional clinical trials and cohort studies
  • Cancer epidemiology
  • Bioinformatics; high-dimensional data analysis
  • Computer-based modelling of stem cells and tissue organisation


9 most important peer-reviewed papers (10 out of 394, Scopus h-index: 87)
  1. Winter A, Stäubert S, Ammon D, …, Löffler M. Smart Medical Information Technology for Healthcare (SMITH). Methods Inf Med. 2018;57(S 01):e92-e105.
  2. Loeffler M, Engel C, Ahnert P, Alfermann D, Arelin K, et al. The LIFE-Adult-Study: objectives and design of a population-based cohort study with 10,000 deeply phenotyped adults in Germany. BMC Public Health. 2015;15:691.
  3. Spada J, Scholz M, Kirsten H, …, Loeffler M, et al. Genome-wide association analysis of actigraphic sleep phenotypes in the LIFE Adult Study. J Sleep Res. 2016;25(6):690-701.
  4. Kharabian Masouleh S, Beyer F, Lampe L, Loeffler M, et al. Gray matter structural networks are associated with cardiovascular risk factors in healthy older adults. J Cereb Blood Flow Metab. 2018;38(2):360-372.
  5. Vojinovic D, Adams HH, Jian X, …, Loeffler M, et al. Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume. Nat Commun. 2018;9(1):3945.
  6. Satizabal CL, Adams HHH, Hibar DP, …, Loeffler M, et al. Genetic architecture of subcortical brain structures in 38,851 individuals. Nat Genet. 2019;51(11):1624-1636.
  7. Yahiaoui-Doktor M, Luck T, Riedel-Heller SG, Loeffler M, Wirkner K, Engel C. Olfactory function is associated with cognitive performance: results from the population-based LIFE-Adult-Study. Alzheimers Res Ther. 2019;11(1):43.
  8. Bloos F, Trips E, Nierhaus A, …, Loeffler M, Reinhart K; for SepNet Critical Care Trials Group. Effect of Sodium Selenite Administration and Procalcitonin-Guided Therapy on Mortality in Patients With Severe Sepsis or Septic Shock: A Randomized Clinical Trial. JAMA Intern Med. 2016;176(9):1266-76.
  9. Chapuy B, Stewart C, Dunford AJ, …, Loeffler M, et al. Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes. Nat Med. 2018;24(5):679-690​.


  • Member of the Program Commission of the System Medicine Consortia (e:MED)
  • Member of the National Steering Committee of the Medical Informatics Initiative (MI-I)
  • Board of Directors of the German National Cohort (GNC)
  • PI of The SMITH Consortium of the Medical Informatics Initiative​​ (since 2018)
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IMISE - Institut für Medizinische Informatik, Statistik und Epidemiologie