Dr. rer. medic. Maria Herberg

Former IZBI Position: POST DOC

Current: Gesundheitsforen Leipzig GmbH Projektmanagerin Medizin & Versorgung

12/2016 PhD at the Institute for Medical Informatics and Biometry (IMB), Medical Faculty Carl Gustav Carus, TU Dresden, Germany
2003 - 2010 Diploma in Bioinformatics at the University of Leipzig, Germany
04/2010 - 07/2010 Research assistant at the Institute for Medical Informatics, Statistics and Epidemiology (IMISE), Medical Faculty, University of Leipzig, Germany
08/2010 - 04/2015 Research assistant at the Institute for Medical Informatics and Biometry (IMB), Medical Faculty Carl Gustav Carus, TU Dresden, Germany
05/2010 - 02/2011 Guest scientist at the Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute, UK
since 08/2010 PhD student at the Institute for Medical Informatics and Biometry (IMB), Medical Faculty Carl Gustav Carus, TU Dresden, Germany (cand. Dr. rer. med.)
since 01/2016 Research assistant at the Interdisciplinary Institute for Bioinformatics (IZBI), Medical Faculty, University of Leipzig, Germany

T. Thalheim, S. Siebert, M. Quaas, M. Herberg, M. R. Schweiger, G. Aust, J. Galle. Epigenetic Drifts during Long-Term Intestinal Organoid Culture. Cells. 2021. 10: 1718.

T. Thalheim, L. Hopp, M. Herberg, S. Siebert, C. Kerner, M. Quaas, M. R. Schweiger, G. Aust, J. Galle. Fighting Against Promoter DNA Hyper-Methylation: Protective Histone Modification Profiles of Stress-Resistant Intestinal Stem Cells. Int J Mol Sci. 2020. 21:

M. Herberg, S. Siebert, M. Quaas, T. Thalheim, K. Rother, M. Hussong, J. Altmuller, C. Kerner, J. Galle, M. R. Schweiger, G. Aust. Loss of Msh2 and a single-radiation hit induce common, genome-wide, and persistent epigenetic changes in the intestine. Clin Epigenetics. 2019. 11: 019-0639.

T. Thalheim, M. Herberg, J. Galle. Linking DNA Damage and Age-Related Promoter DNA Hyper-Methylation in the Intestine. In: Genes 2018.
T. Thalheim, M. Quaas, M. Herberg, U. D. Braumann, C. Kerner, M. Loeffler, G. Aust, J. Galle. Linking stem cell function and growth pattern of intestinal organoids. Dev Biol. 2018. 433: 254-261.

H. Binder, L. Hopp, M. R. Schweiger, S. Hoffmann, F. Juhling, M. Kerick, B. Timmermann, S. Siebert, C. Grimm, L. Nersisyan, A. Arakelyan, M. Herberg, P. Buske, H. Loeffler-Wirth, M. Rosolowski, C. Engel, J. Przybilla, M. Peifer, N. Friedrichs, G. Moeslein, M. Odenthal, M. Hussong, S. Peters, S. Holzapfel, J. Nattermann, R. Hueneburg, W. Schmiegel, B. Royer-Pokora, S. Aretz, M. Kloth, M. Kloor, R. Buettner, J. Galle, M. Loeffler. Genomic and transcriptomic heterogeneity of colorectal tumours arising in Lynch syndrome. J Pathol. 2017. 243: 242-254.
T. Thalheim, M. Herberg, M. Loeffler, J. Galle. The Regulatory Capacity of Bivalent Genes-A Theoretical Approach. Int J Mol Sci. 2017. 18:

M. Herberg, I. Glauche, T. Zerjatke, M. Winzi, F. Buchholz, I. Roeder. Dissecting mechanisms of mouse embryonic stem cells heterogeneity through a model-based analysis of transcription factor dynamics. Journal of The Royal Society Interface. 2016. 13:
M. Herberg, I. Glauche, T. Zerjatke, M. Winzi, F. Buchholz, I. Roeder. Dissecting mechanisms of mouse embryonic stem cells heterogeneity through a model-based analysis of transcription factor dynamics. J R Soc Interface. 2016. 13:

M. Herberg, I. Roeder. Computational modelling of embryonic stem-cell fate control. Development. 2015. 142:
M. Herberg, T. Zerjatke, W. de Back, I. Glauche, I. Roeder. Image-based quantification and mathematical modeling of spatial heterogeneity in ESC colonies. Cytometry Part A. 2015. 87:
M. Herberg, I. Roeder. Computational modelling of embryonic stem-cell fate control. Development. 2015. 142: 2250-60.
M. Herberg, T. Zerjatke, W. de Back, I. Glauche, I. Roeder. Image-based quantification and mathematical modeling of spatial heterogeneity in ESC colonies. Cytometry A. 2015. 87: 481-90.

M. Herberg, T. Kalkan, I. Glauche, A. Smith, I. Roeder. A model-based analysis of culture-dependent phenotypes of mESCs. PLoS ONE. 2014. 9:
M. Herberg, T. Kalkan, I. Glauche, A. Smith, I. Roeder. A model-based analysis of culture-dependent phenotypes of mESCs. PLoS One. 2014. 9: e92496.

N. Scherf, M. Herberg, K. Thierbach, T. Zerjatke, T. Kalkan, P. Humphreys, A. Smith, I. Glauche, I. Roeder. Imaging, quantification and visualization of spatio-temporal patterning in mESC colonies under different culture conditions. Bioinformatics. 2012. 28:
N. Scherf, M. Herberg, K. Thierbach, T. Zerjatke, T. Kalkan, P. Humphreys, A. Smith, I. Glauche, I. Roeder. Imaging, quantification and visualization of spatio-temporal patterning in mESC colonies under different culture conditions. Bioinformatics. 2012. 28: i556-i561.

I. Glauche, M. Herberg, I. Roeder. Nanog variability and pluripotency regulation of embryonic stem cells--insights from a mathematical model analysis. PLoS ONE. 2010. 5:
I. Glauche, M. Herberg, I. Roeder. Nanog variability and pluripotency regulation of embryonic stem cells--insights from a mathematical model analysis. PLoS One. 2010. 5: e11238.

I. Roeder, M. Herberg, M. Horn. An age-structured model of hematopoietic stem cell organization with application to chronic myeloid leukemia. Bulletin of Mathematical Biology. 2009. 71:
I. Roeder, M. Herberg, M. Horn. An "age"-structured model of hematopoietic stem cell organization with application to chronic myeloid leukemia. Bull Math Biol. 2009. 71: 602-26.