study of the evolution of primates, especially interested in the molecular forces that shape phenotypic differences between primate species: What makes us human?
main focus: the impact of transcription factors (TFs) on differences in transcriptomes, gene regulatory networks, and ultimately the phenotype.
major goals: 1. Identify all TFs of each primate species to pinpoint which TFs were born or lost in which lineage, 2. Functionally characterize species-specific TFs and TFs that changed species-specifically, 3. Understand how evolutionary changes in TFs affect gene regulatory network differences between primate species,
I´m also interested in other factors that influence transcriptomic differences, such as the evolution of non-coding RNAs and the epigenome.
S. Berto, A. Perdomo-Sabogal, D. Gerighausen, J. Qin, K. Nowick. A Consensus Network of Gene Regulatory Factors in the Human Frontal Lobe.Front Genet. 2016. 7: 31.
A. Perdomo-Sabogal, K. Nowick, I. Piccini, R. Sudbrak, H. Lehrach, M. L. Yaspo, H. J. Warnatz, R. Querfurth. Human Lineage-Specific Transcriptional Regulation through GA-Binding Protein Transcription Factor Alpha (GABPa).Mol Biol Evol. 2016. 33: 1231-44.
S. R. Kolora, R. Faria, A. Weigert, S. Schaffer, A. Grimm, K. Henle, A. H. Sahyoun, P. F. Stadler, K. Nowick, C. Bleidorn, M. Schlegel. The complete mitochondrial genome of Lacerta bilineata and comparison with its closely related congener L. Viridis.Mitochondrial DNA. 2015. 1-3.
M. D. Laubichler, P. F. Stadler, S. J. Prohaska, K. Nowick. The relativity of biological function.Theory Biosci. 2015. 134: 143-7.
A. M. Andres, K. Nowick. Editorial overview: genetics of human evolution: the genetics of human origins.Curr Opin Genet Dev. 2014. 29: v-vii.
M. R. Höhe, G. M. Church, H. Lehrach, T. Kroslak, S. Palczewski, K. Nowick, S. Schulz, E. K. Suk, T. Huebsch. Multiple haplotype-resolved genomes reveal population patterns of gene and protein diplotypes.Nat Commun. 2014. 5: 5569.
A. Perdomo-Sabogal, S. Kanton, M. B. Walter, K. Nowick. The role of gene regulatory factors in the evolutionary history of humans.Curr Opin Genet Dev. 2014. 29: 60-7.
K. Nowick, M. Carneiro, R. Faria. A prominent role of KRAB-ZNF transcription factors in mammalian speciation?.Trends Genet. 2013. 29: 130-9.
K. Nowick, M. Carneiro, R. Faria. A prominent role of KRAB-ZNF transcription factors in mammalian speciation?. 2012.
A. Leal-Egana, U. D. Braumann, A. Diaz-Cuenca, M. Nowicki, A. Bader. Determination of pore size distribution at the cell-hydrogel interface.J Nanobiotechnology. 2011. 9: 24.
K. Nowick, C. Fields, T. Gernat, D. Caetano-Anolles, N. Kholina, L. Stubbs. Gain, loss and divergence in primate zinc-finger genes: a rich resource for evolution of gene regulatory differences between species.PLoS One. 2011. 6: e21553.
E. K. Suk, G. K. McEwen, J. Duitama, K. Nowick, S. Schulz, S. Palczewski, S. Schreiber, D. T. Holloway, S. McLaughlin, H. Peckham, C. Lee, T. Hübsch, M. R. Höhe. A comprehensively molecular haplotype-resolved genome of a European individual.Genome Res. 2011. 21: 1672-85.