Dr. rer. nat. Jörg Galle

Dr. rer. nat. Jörg Galle

PROJECT LEADER

Tissue Organisation

galle@izbi.uni-leipzig.de

+49 (0) 341 - 97 16674

Room: 442

ACADEMIC CAREER

  • 1995 PhD in Theoretical Physics, University Leipzig
  • IZBI since 2000
  • Group Leader at IZBI (Computational Tissue) since 2005

SCIENTIFIC INTERESTS

PUBLICATIONS

2019 (2)

  • M. Herberg, S. Siebert, M. Quaas, T. Thalheim, K. Rother, M. Hussong, J. Altmuller, C. Kerner, J. Galle, M. R. Schweiger, G. Aust. Loss of Msh2 and a single-radiation hit induce common, genome-wide, and persistent epigenetic changes in the intestine. Clin Epigenetics. 2019. 11: 019-0639.
  • L. Nersisyan, L. Hopp, H. Loeffler-Wirth, J. Galle, M. Loeffler, A. Arakelyan, H. Binder. Telomere Length Maintenance and Its Transcriptional Regulation in Lynch Syndrome and Sporadic Colorectal Carcinoma. Front Oncol. 2019. 9:

2018 (5)

  • L. Hopp, H. Loffler-Wirth, J. Galle, H. Binder. Combined SOM-portrayal of gene expression and DNA methylation landscapes disentangles modes of epigenetic regulation in glioblastoma. Epigenomics. 2018. 10: 745-764.
  • Y. A. Miroshnikova, H. Q. Le, D. Schneider, T. Thalheim, M. Rubsam, N. Bremicker, J. Polleux, N. Kamprad, M. Tarantola, I. Wang, M. Balland, C. M. Niessen, J. Galle, S. A. Wickstrom. Adhesion forces and cortical tension couple cell proliferation and differentiation to drive epidermal stratification. Nat Cell Biol. 2018. 20: 69-80.
  • T. Thalheim, M. Herberg, J. Galle. Linking DNA Damage and Age-Related Promoter DNA Hyper-Methylation in the Intestine. In: Genes 2018.
  • T. Thalheim, L. Hopp, H. Binder, G. Aust, J. Galle. On the Cooperation between Epigenetics and Transcription Factor Networks in the Specification of Tissue Stem Cells. Epigenomes. 2018. 2: 20.
  • T. Thalheim, M. Quaas, M. Herberg, U. D. Braumann, C. Kerner, M. Loeffler, G. Aust, J. Galle. Linking stem cell function and growth pattern of intestinal organoids. Dev Biol. 2018. 433: 254-261.

2017 (5)

  • H. Binder, L. Hopp, M. R. Schweiger, S. Hoffmann, F. Juhling, M. Kerick, B. Timmermann, S. Siebert, C. Grimm, L. Nersisyan, A. Arakelyan, M. Herberg, P. Buske, H. Loeffler-Wirth, M. Rosolowski, C. Engel, J. Przybilla, M. Peifer, N. Friedrichs, G. Moeslein, M. Odenthal, M. Hussong, S. Peters, S. Holzapfel, J. Nattermann, R. Hueneburg, W. Schmiegel, B. Royer-Pokora, S. Aretz, M. Kloth, M. Kloor, R. Buettner, J. Galle, M. Loeffler. Genomic and transcriptomic heterogeneity of colorectal tumours arising in Lynch syndrome. J Pathol. 2017. 243: 242-254.
  • Z. Hamidouche, K. Rother, J. Przybilla, A. Krinner, D. Clay, L. Hopp, C. Fabian, A. Stolzing, H. Binder, P. Charbord, J. Galle. Bistable Epigenetic States Explain Age-Dependent Decline in Mesenchymal Stem Cell Heterogeneity. Stem Cells. 2017. 35: 694-704.
  • K. Keysselt, T. Kreutzmann, K. Rother, C. Kerner, K. Krohn, J. Przybilla, P. Buske, H. Loffler-Wirth, M. Loeffler, J. Galle, G. Aust. Different in vivo and in vitro transformation of intestinal stem cells in mismatch repair deficiency. Oncogene. 2017. 36: 2750-2761.
  • J. Przybilla, L. Hopp, M. Lubbert, M. Loeffler, J. Galle. Targeting DNA hypermethylation: Computational modeling of DNA demethylation treatment of acute myeloid leukemia. Epigenetics. 2017. 12: 886-896.
  • T. Thalheim, M. Herberg, M. Loeffler, J. Galle. The Regulatory Capacity of Bivalent Genes-A Theoretical Approach. Int J Mol Sci. 2017. 18:

2016 (1)

  • T. Thalheim, P. Buske, J. Przybilla, K. Rother, M. Loeffler, J. Galle. Stem cell competition in the gut: insights from multi-scale computational modelling. J R Soc Interface. 2016. 13:

2015 (1)

  • J. Przybilla, T. Rohlf, J. Galle. Towards a Mechanistic Understanding of Epigenetic Dynamics. In: Computational and Statistical Epigenomics, Springer Netherlands , Dordrecht. 2015. 141--160. Ed: Teschendorff, A.E.

2014 (2)

  • P. Buske, J. Przybilla, M. Löffler, J. Galle. The intestinal stem cell niche: a computational tissue approach. Biochem Soc Trans. 2014. 42: 671-7.
  • J. Przybilla, T. Rohlf, M. Löffler, J. Galle. Understanding epigenetic changes in aging stem cells--a computational model approach. Aging Cell. 2014. 13: 320-8.

2013 (2)

  • G. Aust, C. Kerner, S. Gonsior, D. Sittig, H. Schneider, P. Buske, M. Scholz, N. Dietrich, S. Oldenburg, O. N. Karpus, J. Galle, S. Amasheh, J. Hamann. Mice overexpressing CD97 in intestinal epithelial cells provide a unique model for mammalian postnatal intestinal cylindrical growth. Mol Biol Cell. 2013. 24: 2256-68.
  • H. Binder, L. Steiner, J. Przybilla, T. Rohlf, S. Prohaska, J. Galle. Transcriptional regulation by histone modifications: towards a theory of chromatin re-organization during stem cell differentiation. Phys Biol. 2013. 10: 026006.

2012 (4)

  • P. Buske, J. Przybilla, M. Loeffler, N. Sachs, T. Sato, H. Clevers, J. Galle. On the biomechanics of stem cell niche formation in the gut--modelling growing organoids. FEBS J. 2012. 279: 3475-87.
  • J. Przybilla, J. Galle, T. Rohlf. Is adult stem cell aging driven by conflicting modes of chromatin remodeling?. Bioessays. 2012. 34: 841-8.
  • T. Rohlf, L. Steiner, J. Przybilla, S. Prohaska, H. Binder, J. Galle. Modeling the dynamic epigenome: from histone modifications towards self-organizing chromatin. Epigenomics. 2012. 4: 205-19.
  • L. Steiner, L. Hopp, H. Wirth, J. Galle, H. Binder, S. J. Prohaska, T. Rohlf. A global genome segmentation method for exploration of epigenetic patterns. PLoS One. 2012. 7: e46811.

2011 (1)

  • M. Hoffmann, J. P. Kuska, M. Zscharnack, M. Löffler, J. Galle. Spatial organization of mesenchymal stem cells in vitro--results from a new individual cell-based model with podia. PLoS One. 2011. 6: e21960.

2010 (3)

  • H. Binder, H. Wirth, J. Galle. Gene expression density profiles characterize modes of genomic regulation: theory and experiment. J Biotechnol. 2010. 149: 98-114.
  • J. Galle, A. Bader, P. Hepp, W. Grill, B. Fuchs, J. A. Kas, A. Krinner, B. Marquass, K. Müller, J. Schiller, R. M. Schulz, M. von Buttlar, E. von der Burg, M. Zscharnack, M. Löffler. Mesenchymal stem cells in cartilage repair: state of the art and methods to monitor cell growth, differentiation and cartilage regeneration. Curr Med Chem. 2010. 17: 2274-91.
  • A. Krinner, M. Hoffmann, M. Löffler, D. Drasdo, J. Galle. Individual fates of mesenchymal stem cells in vitro. BMC Syst Biol. 2010. 4: 73.

2009 (5)

  • J. Galle, M. Hoffmann, G. Aust. From single cells to tissue architecture-a bottom-up approach to modelling the spatio-temporal organisation of complex multi-cellular systems. J Math Biol. 2009. 58: 261-283.
  • J. Galle, L. Preziosi. Multiphase and Individual Cell-Based Models of Tumour Growth. In: Mathematics, Developmental Biology and Tumour Growth, American Mathematical Society 2009. 492: 103-123. Ed: Giraldez, F. and Herrero, M. A.
  • J. Galle, L. Preziosi, A. Tosin. Contact inhibition of growth described using a multiphase model and an individual cell based model. Applied Mathematics Letters. 2009. 22: 1483-1490.
  • A. Krinner, M. Zscharnack, A. Bader, D. Drasdo, J. Galle. Impact of oxygen environment on mesenchymal stem cell expansion and chondrogenic differentiation. Cell Prolif. 2009. 42: 471-84.
  • M. Zscharnack, C. Poesel, J. Galle, A. Bader. Low oxygen expansion improves subsequent chondrogenesis of ovine bone-marrow-derived mesenchymal stem cells in collagen type I hydrogel. Cells Tissues Organs. 2009. 190: 81-93.

2008 (1)

  • M. Hoffmann, H. H. Chang, S. Huang, D. E. Ingber, M. Löffler, J. Galle. Noise-driven stem cell and progenitor population dynamics. PLoS One. 2008. 3: e2922.

2006 (2)

  • J. Galle, G. Aust, G. Schaller, T. Beyer, D. Drasdo. Individual cell-based models of the spatial-temporal organization of multicellular systems--achievements and limitations. Cytometry A. 2006. 69: 704-10.
  • J. Galle, D. Sittig, I. Hanisch, M. Wobus, E. Wandel, M. Loeffler, G. Aust. Individual cell-based models of tumor-environment interactions: Multiple effects of CD97 on tumor invasion. Am J Pathol. 2006. 169: 1802-11.

2002 (1)

  • U.D. Braumann, J. Galle. Untersuchungen zur Rekonstruktion netzartiger Tumorinvasionsfronten anhand histologischer Serienschnitte. In: Bildverarbeitung für die Medizin 2002 -Algorithmen, Systeme, Anwendungen, Springer-Verlag 2002. 239-242. Ed: Meiler, M. and Saupe, D. and Kruggel, F. and Handels, H. and Lehmann, Th.

MISCELLANEOUS

  • 2006-2010 scientific coordinator MS CartPro (BMBF Initiative QuantPro): Multiparametric Monitoring and Steering of Mesenchymal Stem Cell derived Cartilage Formation in 3D Production Systems
  • 2011-2016 supervisor MAGE (BMBF Initiative GerontoSys II): A Model of the Aging Epigenome
  • 2012-2015 co-investigator HNPCC-Sys (BMBF Initiative CancerSys): Systems Biology of Hereditary Colorectal Cancer
  • 2013-2016 principal investigator SPP1463 (DFG): Epigenetic Regulation of normal hematopoiesis and its dysregulation in myeloid neoplasia
  • 2014-2019 principal investigator INDRA (BMBF Initiative e:Bio) A model of the Intestinal Stem Cell Niche: Development, Regeneration and Ageing