Dr. rer. nat Henry Löffler-Wirth

Dr. rer. nat Henry Löffler-Wirth

PROJECT LEADER / RESEARCH GROUP LEADER

Omics bioinformatics for health and systems biology, Algorithms for complex data in life sciences

wirth@izbi.uni-leipzig.de

+49 (0) 341 - 97 16696

Room: 326

ACADEMIC CAREER

  • Diploma in “Computer Science”, main course “Artificial Intelligence” Diploma thesis: “Modeling of a cellular automaton based on dendritic cells and application in pattern recognition.” Chemnitz University of Technology, 2002 - 2008
  • PhD student, “HIGRADE”-scholarship holder, University Helmholtz centre for environmental research (UFZ), Leipzig & Interdisciplinary Centre for Bioinformatics (IZBI), Leipzig, 2008 - 2011
  • PhD in “Computer Science”, subject “Bioinformatics”, PhD thesis: “Analysis of large-scale molecular biological data using self-organizing maps.”, IZBI, University Leipzig, 2011 - 2012
  • PhD student, research fellow, Interdisciplinary Research Cluster of Genetic Factors, Clinical Phenotypes and Environment - LIFE, Leipzig University, 2011 - 2012
  • PostDoc, research fellow, Interdisciplinary Centre for Bioinformatics - IZBI, Leipzig University, 2012 - 2014
  • Leader of Junior Research Group ‘Algorithms for complex data in life sciences’, IZBI, Leipzig University, since 2014

SCIENTIFIC INTERESTS

I studied Computer Science with major in Artificial Intelligence. After Diploma, I switched to Bioinformatics, as the combination of algorithms and biology is both challenging and interesting. I am programmer since 25 years and developed data analytics tools since more than a decade.
MAIN TOPICS
  • Systems biology of cancer (lymphoma, glioma, melanoma & hereditary colon cancer): Analysis of microarray and RNA-seq data to develop a systems view on basal mechanisms of tumor genesis and progression
  • Analysis of body scanner data, evaluation of body types and association to diseases
  • Trajectories in single cell differentiation experiments
  • molecular mechanisms and impact of genomic regulation (mol. phenotypes of the population of Leipzig)
  • data mining and integration of high throughput OMICs data

PUBLICATIONS

2022 (3)

  • Hans Binder, Maria Schmidt, Lydia Hopp, Suren Davitavyan, Arsen Arakelyan, Henry Loeffler-Wirth. Integrated Multi-Omics Maps of Lower-Grade Gliomas. Cancers. 2022. 14:
  • Henry Loeffler-Wirth, Lydia Hopp, Maria Schmidt, Roksana Zakharyan, Arsen Arakelyan, Hans Binder. The Transcriptome and Methylome of the Developing and Aging Brain and Their Relations to Gliomas and Psychological Disorders. Cells. 2022. 11: 362.
  • Maria Nikoghosyan, Henry Loeffler-Wirth, Suren Davidavyan, Hans Binder, Arsen Arakelyan. Projection of High-Dimensional Genome-Wide Expression on SOM Transcriptome Landscapes. BioMedInformatics. 2022. 2: 62-76.

2021 (7)

  • Hans Binder, Maria Schmidt, Henry Loeffler-Wirth, Lena Suenke Mortensen, Manfred Kunz. Melanoma Single-Cell Biology in Experimental and Clinical Settings. Journal of Clinical Medicine. 2021. 10: 506.
  • Siras Hakobyan, Henry Loeffler-Wirth, Arsen Arakelyan, Hans Binder, Manfred Kunz. A Transcriptome-Wide Isoform Landscape of Melanocytic Nevi and Primary Melanomas Identifies Gene Isoforms Associated with Malignancy. International Journal of Molecular Sciences. 2021. 22: 7165.
  • R. Minhas, H. Loeffler-Wirth, Y. H. Siddiqui, T. Obrębski, S. Vashisht, K. A. Nahia, A. Paterek, A. Brzozowska, L. Bugajski, K. Piwocka, V. Korzh, H. Binder, C. L. Winata. Transcriptome profile of the sinoatrial ring reveals conserved and novel genetic programs of the zebrafish pacemaker. BMC Genomics. 2021. 22: 715.
  • Maria Schmidt, Mamoona Arshad, Stephan H. Bernhart, Siras Hakobyan, Arsen Arakelyan, Henry Loeffler-Wirth, Hans Binder. The Evolving Faces of the SARS-CoV-2 Genome. Viruses. 2021. 13: 1764.
  • Maria Schmidt, Lena Sünke Mortensen, Henry Loeffler-Wirth, Corinna Kosnopfel, Knut Krohn, Hans Binder, Manfred Kunz. Single-cell trajectories of melanoma cell resistance to targeted treatment. Cancer biology & medicine. 2021.
  • E. Willscher, L. Hopp, M. Kreuz, M. Schmidt, S. Hakobyan, A. Arakelyan, H. Loeffler-Wirth, H. Binder, et al. High-Resolution Cartography of the Transcriptome and Methylome Landscapes of Diffuse Gliomas. Cancers (Basel). 2021. 13:
  • Johannes Wolf, Edith Willscher, Henry Loeffler-Wirth, Maria Schmidt, Gunter Flemming, Marlen Zurek, Holm H. Uhlig, Norman Händel, Hans Binder. Deciphering the Transcriptomic Heterogeneity of Duodenal Coeliac Disease Biopsies. International Journal of Molecular Sciences. 2021. 22: 2551.

2020 (8)

  • C. Engelmann, M. Sheikh, S. Sharma, T. Kondo, H. Loeffler-Wirth, Y. B. Zheng, S. Novelli, A. Hall, A. J. C. Kerbert, J. Macnaughtan, R. Mookerjee, A. Habtesion, N. Davies, T. Ali, S. Gupta, F. Andreola, R. Jalan. Toll-like receptor 4 is a therapeutic target for prevention and treatment of liver failure. J Hepatol. 2020. 73: 102-112.
  • A. Frenzel, H. Binder, N. Walter, K. Wirkner, M. Loeffler, H. Loeffler-Wirth. The aging human body shape. NPJ Aging Mech Dis. 2020. 6: 5.
  • H. Loeffler-Wirth, J. Reikowski, S. Hakobyan, J. Wagner, H. Binder. oposSOM-Browser: an interactive tool to explore omics data landscapes in health science. 2020.
  • H. Loeffler-Wirth, M. Schmidt, H. Binder. Covid-19 Transmission Trajectories-Monitoring the Pandemic in the Worldwide Context. Viruses. 2020. 12:
  • M. Nikoghosyan, M. Schmidt, K. Margaryan, H. Loeffler-Wirth, A. Arakelyan, H. Binder. SOMmelier—Intuitive Visualization of the Topology of Grapevine Genome Landscapes Using Artificial Neural Networks. MDPI Journals Genes. 2020. 11: 21.
  • M. Schmidt, L. Hopp, A. Arakelyan, H. Kirsten, H. Loeffler-Wirth, H. Binder, et al. The Human Blood Transcriptome in a Large Population Cohort and Its Relation to Aging and Health. Front Big Data. 2020. 3: 548873.
  • M. Schmidt, H. Loeffler-Wirth, H. Binder. Developmental scRNAseq Trajectories in Gene- and Cell-State Space-The Flatworm Example. Genes (Basel). 2020. 11:
  • M. Schmidt, L. Hopp, A. Arakelyan, H. Kirsten, C. Engel, K. Wirkner, M. Loeffler, H. Loeffler-Wirth, H. Binder, et al. The Human Blood Transcriptome in a Large Population Cohort and Its Relation to Aging and Health. 2020.

2019 (5)

  • A. Arakelyan, L. Nersisyan, M. Nikoghosyan, S. Hakobyan, A. Simonyan, L. Hopp, H. Loeffler-Wirth, H. Binder. Transcriptome-Guided Drug Repositioning. Pharmaceutics. 2019. 11:
  • H. Binder, E. Willscher, H. Loeffler-Wirth, L. Hopp, D. T. W. Jones, S. M. Pfister, M. Kreuz, D. Gramatzki, E. Fortenbacher, B. Hentschel, M. Loeffler, et al. DNA methylation, transcriptome and genetic copy number signatures of diffuse cerebral WHO grade II/III gliomas resolve cancer heterogeneity and development. Acta Neuropathol Commun. 2019. 7: 019-0704.
  • H. Loeffler-Wirth, M. Kreuz, L. Hopp, A. Arakelyan, A. Haake, S. B. Cogliatti, A. C. Feller, M. L. Hansmann, D. Lenze, P. Moller, H. K. Muller - Hermelink, E. Fortenbacher, E. Willscher, G. Ott, A. Rosenwald, C. Pott, C. Schwaenen, H. Trautmann, S. Wessendorf, H. Stein, M. Szczepanowski, L. Trumper, M. Hummel, W. Klapper, R. Siebert, M. Loeffler, H. Binder. A modular transcriptome map of mature B cell lymphomas. Genome Med. 2019. 11: 019-0637.
  • L. Nersisyan, L. Hopp, H. Loeffler-Wirth, J. Galle, M. Loeffler, A. Arakelyan, H. Binder. Telomere Length Maintenance and Its Transcriptional Regulation in Lynch Syndrome and Sporadic Colorectal Carcinoma. Front Oncol. 2019. 9:
  • Nikoghosyan M, S Hakobyan, A Hovhannisyan, H. Loeffler-Wirth, H. Binder, A. Arakelyan. Population Levels Assessment of the Distribution of Disease-Associated Variants With Emphasis on Armenians – A Machine Learning Approach. Frontiers in Genetics. 2019. 10:

2018 (5)

  • L. Hopp, H. Loffler-Wirth, J. Galle, H. Binder. Combined SOM-portrayal of gene expression and DNA methylation landscapes disentangles modes of epigenetic regulation in glioblastoma. Epigenomics. 2018. 10: 745-764.
  • L. Hopp, H. Loeffler-Wirth, L. Nersisyan, A. Arakelyan, H. Binder. Footprints of Sepsis Framed Within Community Acquired Pneumonia in the Blood Transcriptome. Front Immunol. 2018. 9: 1620.
  • M. Kunz, H. Loffler-Wirth, M. Dannemann, E. Willscher, G. Doose, J. Kelso, T. Kottek, B. Nickel, L. Hopp, J. Landsberg, S. Hoffmann, T. Tuting, P. Zigrino, C. Mauch, J. Utikal, M. Ziemer, H. J. Schulze, M. Holzel, A. Roesch, S. Kneitz, S. Meierjohann, A. Bosserhoff, H. Binder, M. Schartl. RNA-seq analysis identifies different transcriptomic types and developmental trajectories of primary melanomas. Oncogene. 2018. 37: 6136-6151.
  • H. Loeffler-Wirth, H. Binder, E. Willscher, T. Gerber, M. Kunz. Pseudotime Dynamics in Melanoma Single-Cell Transcriptomes Reveals Different Mechanisms of Tumor Progression. Biology. 2018. 7: 23.
  • H. Loeffler-Wirth, M. Vogel, T. Kirsten, F. Glock, T. Poulain, A. Korner, M. Loeffler, W. Kiess, H. Binder. Longitudinal anthropometry of children and adolescents using 3D-body scanning. PLoS One. 2018. 13: e0203628.

2017 (7)

  • A. Arakelyan, L. Nersisyan, D. Poghosyan, L. Khondkaryan, A. Hakobyan, H. Loffler-Wirth, E. Melanitou, H. Binder. Autoimmunity and autoinflammation: A systems view on signaling pathway dysregulation profiles. PLoS One. 2017. 12: e0187572.
  • H. Binder, L. Hopp, M. R. Schweiger, S. Hoffmann, F. Juhling, M. Kerick, B. Timmermann, S. Siebert, C. Grimm, L. Nersisyan, A. Arakelyan, M. Herberg, P. Buske, H. Loeffler-Wirth, M. Rosolowski, C. Engel, J. Przybilla, M. Peifer, N. Friedrichs, G. Moeslein, M. Odenthal, M. Hussong, S. Peters, S. Holzapfel, J. Nattermann, R. Hueneburg, W. Schmiegel, B. Royer-Pokora, S. Aretz, M. Kloth, M. Kloor, R. Buettner, J. Galle, M. Loeffler. Genomic and transcriptomic heterogeneity of colorectal tumours arising in Lynch syndrome. J Pathol. 2017. 243: 242-254.
  • M. Cakir, H. Wirth, A. Arakelyan, H. Binder. Dysregulated signal progagation in a MYC-associated Booleas gene network in B-cell lymphoma. Biology. 2017. 2: 1-11.
  • J. G. Camp, K. Sekine, T. Gerber, H. Loeffler-Wirth, H. Binder, M. Gac, S. Kanton, J. Kageyama, G. Damm, D. Seehofer, L. Belicova, M. Bickle, R. Barsacchi, R. Okuda, E. Yoshizawa, M. Kimura, H. Ayabe, H. Taniguchi, T. Takebe, B. Treutlein. Multilineage communication regulates human liver bud development from pluripotency. Nature. 2017. 546: 533-538.
  • T. Gerber, E. Willscher, H. Loeffler-Wirth, L. Hopp, D. Schadendorf, M. Schartl, U. Anderegg, G. Camp, B. Treutlein, H. Binder, M. Kunz. Mapping heterogeneity in patient-derived melanoma cultures by single-cell RNA-seq. Oncotarget. 2017. 8: 846-862.
  • K. Keysselt, T. Kreutzmann, K. Rother, C. Kerner, K. Krohn, J. Przybilla, P. Buske, H. Loffler-Wirth, M. Loeffler, J. Galle, G. Aust. Different in vivo and in vitro transformation of intestinal stem cells in mismatch repair deficiency. Oncogene. 2017. 36: 2750-2761.
  • H. Loeffler-Wirth, M. Vogel, T. Kirsten, F. Glock, T. Poulain, A. Korner, M. Loeffler, W. Kiess, H. Binder. Body typing of children and adolescents using 3D-body scanning. PLoS One. 2017. 12: e0186881.

2016 (6)

  • A. Arakelyan, L. Nersisyan, M. Pentrak, H. Loeffler-Wirth, H. Binder. Cartography of Pathway Signal Perturbations Identifies Distinct Molecular Pathomechanisms in Malignant and Chronic Lung Diseases. Front Genet. 2016. 7: 79.
  • T. Gerber, E. Willscher, H. Loeffler-Wirth, L. Hopp, D. Schadendorf, M. Schartl, U. Anderegg, G. Camp, B. Treutlein, H. Binder, M. Kunz. Mapping heterogeneity in patient-derived melanoma cultures by single-cell RNA-seq. Oncotarget. 2016.
  • H. Loeffler-Wirth, E. Willscher, P. Ahnert, K. Wirkner, C. Engel, M. Loeffler, H. Binder. Novel Anthropometry Based on 3D-Bodyscans Applied to a Large Population Based Cohort. PLoS One. 2016. 11: e0159887.
  • H. Loeffler-Wirth, E. Willscher, P. Ahnert, K. Wirkner, C. Engel, M. Loeffler, H. Binder. Novel Anthropometry Based on 3D-Bodyscans Applied to a Large Population Based Cohort. PLoS One. 2016. 11: e0159887.
  • L. Nersisyan, H. Loeffler-Wirth, A. Arakelyan, H. Binder. Gene set- and pathway- centered cancer - A bioinformatics perspective. . International Journal of Knowledge Discovery in Bioinformatics. 2016.
  • L. Rohani, C. Fabian, H. Holland, Y. Naaldijk, R. Dressel, H. Loeffler-Wirth, H. Binder, A. Arnold, A. Stolzing. Generation of human induced pluripotent stem cells using non-synthetic mRNA. Stem Cell Res. 2016. 16: 662-72.

2015 (8)

  • H. Binder, L. Hopp, K. Lembcke, H. Wirth. Personalized disease phenotypes from massive omics data. In: Big Data Analytics in Bioinformatics and Healthcare , IGI Global , Hershey, PA, USA. 2015. 359-378. Ed: Baoying, Wang and Ruowang, Li and William, Perrizo.
  • H. Binder, H. Wirth. Analysis of Large-Scale OMIC Data Using Self Organizing Maps. In: Encyclopedia of Information Science and Technology, Third Edition, IGI Global , Hershey, PA, USA. 2015. 1642-1653. Ed: Mehdi, Khosrow-Pour.
  • L. Hopp, H. Löffler-Wirth, H. Binder. Epigenetic Heterogeneity of B-Cell Lymphoma: DNA Methylation, Gene Expression and Chromatin States. Genes (Basel). 2015. 6: 812-40.
  • L. Hopp, L. Nersisyan, H. Löffler-Wirth, A. Arakelyan, H. Binder. Epigenetic Heterogeneity of B-Cell Lymphoma: Chromatin Modifiers. Genes (Basel). 2015. 6: 1076-112.
  • L. Hopp, E. Willscher, H. Löffler-Wirth, H. Binder. Function Shapes Content: DNA-Methylation Marker Genes and their Impact for Molecular Mechanisms of Glioma. Journal of Cancer Research Updates. 2015. 11/2015: 127-148.
  • V. Kumar, J. E. Bouameur, J. Bar, R. H. Rice, H. T. Hornig-Do, D. R. Roop, N. Schwarz, S. Brodesser, S. Thiering, R. E. Leube, R. J. Wiesner, P. Vijayaraj, C. B. Brazel, S. Heller, H. Binder, H. Loeffler-Wirth, P. Seibel, T. M. Magin. A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity. J Cell Biol. 2015. 211: 1057-75.
  • H. Löffler-Wirth, M. Kalcher, H. Binder. oposSOM: R-package for high-dimensional portraying of genome-wide expression landscapes on bioconductor. Bioinformatics. 2015. 31: 3225-7.
  • M. Weller, R. G. Weber, E. Willscher, V. Riehmer, B. Hentschel, M. Kreuz, J. Felsberg, U. Beyer, H. Löffler-Wirth, K. Kaulich, J. P. Steinbach, C. Hartmann, D. Gramatzki, J. Schramm, M. Westphal, G. Schackert, M. Simon, T. Martens, J. Bostrom, C. Hagel, M. Sabel, D. Krex, J. C. Tonn, W. Wick, S. Noell, U. Schlegel, B. Radlwimmer, T. Pietsch, M. Löffler, A. von Deimling, H. Binder, G. Reifenberger. Molecular classification of diffuse cerebral WHO grade II/III gliomas using genome- and transcriptome-wide profiling improves stratification of prognostically distinct patient groups. Acta Neuropathol. 2015. 129: 679-93.

2014 (10)

  • A. Arakelyan, L. Nersisyan, H. Wirth, H. Binder. Mining common pathway deregulation profiles in lung diseases. European Respiratory Journal. 2014. 44:
  • H. Binder, H. Wirth, A. Arakelyan, K. Lembcke, E. Tiys, V. Ivanisenko, N. Kolchanov, A. Kononikhin, I. Popov, E. Nikolaev, L. Pastushkova, I. Larina. Time-course human urine proteomics in space-flight simulation experiments. BMC Genomics. 2014. 15: S2.
  • M. V. Cakir, H. Binder, H. Wirth. Profiling of Genetic Switches using Boolean Implications in Expression Data. J Integr Bioinform. 2014. 11: 246.
  • M. V. Cakir, H. Wirth, L. Hopp, H. Binder. MicroRNA Expression Landscapes in Stem Cells, Tissues, and Cancer. Methods Mol Biol. 2014. 1107: 279-302.
  • Mehmet Volkan Çakir, Henry Wirth, Lydia Hopp, Hans Binder. MicroRNA Expression Landscapes in Stem Cells, Tissues, and Cancer. In: miRNomics: MicroRNA Biology and Computational Analysis, Humana Press 2014. 1107: 279-302. Ed: Yousef, Malik and Allmer, Jens.
  • P. Charbord, C. Pouget, H. Binder, F. Dumont, G. Stik, P. Levy, F. Allain, C. Marchal, J. Richter, B. Uzan, F. Pflumio, F. Letourneur, H. Wirth, E. Dzierzak, D. Traver, T. Jaffredo, C. Durand. A systems biology approach for defining the molecular framework of the hematopoietic stem cell niche. Cell Stem Cell. 2014. 15: 376-91.
  • L. Nersisyan, H. Loeffler-Wirth, A. Arakelyan, H. Binder. Gene Set- and Pathway- Centered Knowledge Discovery Assigns Transcriptional Activation Patterns in Brain, Blood, and Colon Cancer: A Bioinformatics Perspective. International Journal of Knowledge Discovery in Bioinformatics (IJKDB). 2014. 4: 46-69.
  • G. Reifenberger, R. G. Weber, V. Riehmer, K. Kaulich, E. Willscher, H. Wirth, J. Gietzelt, B. Hentschel, M. Westphal, M. Simon, G. Schackert, J. Schramm, J. Matschke, M. C. Sabel, D. Gramatzki, J. Felsberg, C. Hartmann, J. P. Steinbach, U. Schlegel, W. Wick, B. Radlwimmer, T. Pietsch, J. C. Tonn, A. von Deimling, H. Binder, M. Weller, M. Loeffler. Molecular characterization of long-term survivors of glioblastoma using genome- and transcriptome-wide profiling. Int J Cancer. 2014.
  • H. Wirth, M. V. Cakir, L. Hopp, H. Binder. Analysis of MicroRNA Expression Using Machine Learning. Methods Mol Biol. 2014. 1107: 257-78.
  • H. Wirth, M.V. Çakir, L. Hopp, H. Binder. Analysis of MicroRNA Expression Using Machine Learning. In: miRNomics: MicroRNA Biology and Computational Analysis, Humana Press 2014. 1107: 257-278. Ed: Yousef, Malik and Allmer, Jens.

2013 (3)

  • L. Hopp, H. Wirth, M. Fasold, H. Binder. Portraying the expression landscapes of cancer subtypes: a glioblastoma multiforme and prostate cancer case study. Systems Biomedicine. 2013. 1:
  • A. Oberbach, N. Jehmlich, N. Schlichting, M. Heinrich, S. Lehmann, H. Wirth, H. Till, J. U. Stolzenburg, U. Volker, V. Adams, J. Neuhaus. Molecular fingerprint of high fat diet induced urinary bladder metabolic dysfunction in a rat model. PLoS One. 2013. 8: e66636.
  • H. Wirth. Analyse molekularbiologischer Daten mittels Self-organizing Maps. In: Ausgezeichnete Informatikdissertationen Teil: 2012, Hölldobler, S. Gesellschaft für Informatik e.V., Bonn , Bonn. 2013. Lecture Notes in Informatics D-13: 291-300. Ed: GI-Edition.

2012 (4)

  • A. Arnold, Y.M. Naaldijk, C. Fabian, H. Wirth, H. Binder, G. Nikkhah, L. Armstrong, A. Stolzing. Reprogramming of Human Huntington Fibroblasts Using mRNA. ISRN Cell Biology. 2012. 2012: 12.
  • L. Steiner, L. Hopp, H. Wirth, J. Galle, H. Binder, S. J. Prohaska, T. Rohlf. A global genome segmentation method for exploration of epigenetic patterns. PLoS One. 2012. 7: e46811.
  • H. Wirth, M. von Bergen, H. Binder. Mining SOM expression portraits: feature selection and integrating concepts of molecular function. BioData Min. 2012. 5: 18.
  • H. Wirth, M. von Bergen, J. Murugaiyan, U. Rosler, T. Stokowy, H. Binder. MALDI-typing of infectious algae of the genus Prototheca using SOM portraits. J Microbiol Methods. 2012. 88: 83-97.

2011 (5)

  • H. Binder, M. Fasold, L. Hopp, V. Cakir, M. von Bergen, H. Wirth. Genomic and molecular Phenotypic Portraits - Exploring The "Omes" With Individual Resolution. In: 6th International Symposium on Health Informatics and Bioinformatics (HIBIT) 2011. 115-122. Ed: Explore, IEEE.
  • N. Morbt, J. Tomm, R. Feltens, I. Mogel, S. Kalkhof, K. Murugesan, H. Wirth, C. Vogt, H. Binder, I. Lehmann, M. von Bergen. Chlorinated benzenes cause concomitantly oxidative stress and induction of apoptotic markers in lung epithelial cells (A549) at nonacute toxic concentrations. J Proteome Res. 2011. 10: 363-78.
  • A. Oberbach, M. Blüher, H. Wirth, H. Till, P. Kovacs, Y. Kullnick, N. Schlichting, J. M. Tomm, U. Rolle-Kampczyk, J. Murugaiyan, H. Binder, A. Dietrich, M. von Bergen. Combined proteomic and metabolomic profiling of serum reveals association of the complement system with obesity and identifies novel markers of body fat mass changes. J Proteome Res. 2011. 10: 4769-88.
  • H. Wirth, M. Löffler, M. von Bergen, H. Binder. Expression cartography of human tissues using self organizing maps. BMC Bioinformatics. 2011. 12: 306.
  • H. Wirth, M. von Bergen, J. Murugaiyan, U. Rosler, T. Stokowy, H. Binder. MALDI-typing of infectious algae of the genus Prototheca using SOM portraits. J Microbiol Methods. 2011. 88: 83-97.

2010 (1)

  • H. Binder, H. Wirth, J. Galle. Gene expression density profiles characterize modes of genomic regulation: theory and experiment. J Biotechnol. 2010. 149: 98-114.

2009 (1)

  • M.v. Bergen, A. Eidner, F. Schmidt, J. Murugaiyan, H. Wirth, H. Binder, T. Maier, U. Roesler. Identification of harmless and pathogenic algae of the genus Prototheca by MALDI-MS. PROTEOMICS - CLINICAL APPLICATIONS. 2009. 3: 774-784.

2007 (1)

  • D. Voigt, H. Wirth, W. Dilger. A Computational Model for the Cognitive Immune System Theory Based on Learning Classifier Systems. 2007. 264-275.

MISCELLANEOUS

  • June 2010 Lipari School on Bioinformatics and Computational Biology, Lipari, Italy, Summer School: “Statistical and Machine Learning Methods in Computational Biology”
  • February 2011 Australian National University - ANU, Canberra, Australia, Research stay
  • since 2016 Hindawi ‘Advances in Bioinformatics’Member of Editorial Board

click here for : Curriculum vitae (pdf)