Dr. Georg Künze
.
ACADEMIC CAREER
- Since 2021, Research group leader at Institute for Drug Discovery and Interdisciplinary Centre for Bioinformatics, University of Leipzig
- 2016 – 2020, Postdoc, Vanderbilt University, Nashville, USA, in the lab of Prof. Jens Meiler
- 2011 – 2015, PhD, University of Leipzig, Institute for Biophysics, in the lab of Prof. Daniel Huster
- 2009 – 2010, MSc. Biochemistry, University of Leipzig
- 2009, Erasmus student, University of Cardiff, Cardiff, UK
- 2006 – 2008, BSc. Biochemistry, University of Leipzig
SCIENTIFIC INTERESTS
My lab uses computational tools and simulations together with wetlab experiments to obtain atomic-level insight into the structural and dynamical behavior of biomolecules. The main topics of my lab are molecular simulations of membrane proteins and drug delivery systems, computational design of enzymes and protein binders, and development of bioinformatics tools for applications in structural biology. .CURRENT PROJECTS
- Computational design of plastic degrading enzymes (JTF/EFRE)
- Molecular dynamics simulations of protease-activated receptors (CRC 1423, DFG)
- Proteome-wide protein modeling and variant effect predictions for Arabidopsis thaliana (CRC1664, DFG)
- Design of helical peptide bundles to study the CISS effect (TRR 386, DFG)
- Computational design of protein binders for the treatment of AMD (ISOS, EU Pathfinder)
- Discovery of novel natural biomolecules from aquatic extremophiles (EXPLORA, EU Horizon)
- Simulation of mRNA-lipid nanoparticle uptake and transport mechanisms (KIWI ZiEL, BMWK)
https://kuenzelab.org/
.PUBLICATIONS
2024 (2)
- A. Elwakiel, D. Gupta, R. Rana, J. Manoharan, M. M. Al-Dabet, S. Ambreen, S. Fatima, S. Zimmermann, A. Mathew, Z. Li, K. Singh, A. Gupta, S. Pal, A. Sulaj, S. Kopf, C. Schwab, R. Baber, R. Geffers, T. Götze, B. Alo, C. Lamers, P. Kluge, G. Kuenze, S. Kohli, T. Renné, K. Shahzad, B. Isermann. Factor XII signaling via uPAR-integrin β1 axis promotes tubular senescence in diabetic kidney disease. Nat Commun. 2024. 15: 7963.
- J. Manoharan, R. Rana, G. Kuenze, D. Gupta, A. Elwakiel, S. Ambreen, H. Wang, K. Banerjee, S. Zimmermann, K. Singh, A. Gupta, S. Fatima, S. Kretschmer, L. Schaefer, J. Zeng-Brouwers, C. Schwab, M. M. Al-Dabet, I. Gadi, H. Altmann, T. Koch, D. M. Poitz, R. Baber, S. Kohli, K. Shahzad, R. Geffers, M. A. Lee-Kirsch, U. Kalinke, J. Meiler, N. Mackman, B. Isermann. Tissue factor binds to and inhibits interferon-α receptor 1 signaling. Immunity. 2024. 57: 68-85 e11.
2023 (1)
- B. Marlow, G. Kuenze, J. Meiler, J. Koehler Leman. Docking cholesterol to integral membrane proteins with Rosetta. PLoS Comput Biol. 2023. 19: e1010947.