SINGLE-CELL TRAJECTORIES OF MELANOMA CELL RESISTANCE TO TARGETED TREATMENT Abstract Objective: Cellular heterogeneity is regarded as a major factor affecting treatment response and resistance in malignant melanoma. Recent developments in single-cell sequencing technology have provided deeper insights into these mechanisms. Methods: Here, we analyzed a BRAFV600E-mutant melanoma cell line by single-cell RNA-seq under various conditions: […]