Dr. Matthias Elgeti

ACADEMIC CAREER

• since 2023 German Network for Bioinformatics, IZBI, Leipzig University
• since 2023 Elgeti Lab, Institute for Drug Discovery, Medical School, Leipzig University
• 2020 own independent research program at UCLA
• postdoc training in the laboratory of Dr. Wayne Hubbell at UCLA
• PhD in Biophysics from the Humboldt Universitaet zu Berlin under the guidance of Drs. Klaus Peter Hofmann and Franz Bartl

SCIENTIFIC INTERESTS

Proteins “at work” constantly change shape in order to interact with binding partners such as ligands or other proteins. Membrane proteins in particular exhibit a high degree of flexibility to control transmembrane signaling processes. In the Elgeti Lab, we utilize electron paramagnetic resonance (EPR) spectroscopy and other biophysical, biochemical, and computational methods to characterize and understand membrane proteins. Our research connects protein structure to function and contributes to the development of more efficacious therapeutics with fewer side effects.

CURRENT PROJECT

https://elgetilab.github.io/

PUBLICATIONS

2024 (3)

• J. Belyaeva, M. Elgeti. Exploring protein structural ensembles: Integration of sparse experimental data from electron paramagnetic resonance spectroscopy with molecular modeling methods. Elife. 2024. 13:
• Mengzhen Chen, Tamás Kálai, Duilio Cascio, Michael D. Bridges, Julian P. Whitelegge, Matthias Elgeti, Wayne L. Hubbell. A Highly Ordered Nitroxide Side Chain for Distance Mapping and Monitoring Slow Structural Fluctuations in Proteins. Applied Magnetic Resonance. 2024. 55: 251-277.
• J. Zhao, M. Elgeti, E. S. O'Brien, C. P. Sár, A. Ei Daibani, J. Heng, X. Sun, E. White, T. Che, W. L. Hubbell, B. K. Kobilka, C. Chen. Ligand efficacy modulates conformational dynamics of the µ-opioid receptor. Nature. 2024. 629: 474-480.

2023 (2)

• Farha Khan, Matthias Elgeti, Samuel Grandfield, Aviv Paz, Fiona B. Naughton, Frank V. Marcoline, Thorsten Althoff, Natalia Ermolova, Ernest M. Wright, Wayne L. Hubbell, Michael Grabe, Jeff Abramson. Membrane potential accelerates sugar uptake by stabilizing the outward facing conformation of the Na/glucose symporter vSGLT. Nature communications. 2023. 14: 7511.
• Marcel M. Wygas, Jeannette M. Laugwitz, Peter Schmidt, Matthias Elgeti, Anette Kaiser. Dynamics of the Second Extracellular Loop Control Transducer Coupling of Peptide-Activated GPCRs. 2023. 24:

MISCELLANEOUS