Dr. rer. nat. Bioinformatik Maria Schmidt

ACADEMIC CAREER

• Bachelor of Science Biology, BSc degree in Biology, Leipzig University, Germany, 2012
• Master of Science Bioinformatics mSc degree in Bioinformatics, Leipzig University, 2017
• research assistant at IZBI since 2016
• scientific employees IZBI since 2019
• Phd in Bioinformatics, Dr. rer. nat. Leipzig University, 2023

SCIENTIFIC INTERESTS

• Systems biology and epidemiology of health, diseases and cancer
• Molecular mechanisms and impact of genomic regulation
• Data mining and integration of high throughput OMICs data

PUBLICATIONS

2023 (3)

• Ohanes Ashekyan, Nerses Shahbazyan, Yeva Bareghamyan, Anna Kudryavzeva, Daria Mandel, Maria Schmidt, Henry Loeffler-Wirth, Mohamed Uduman, Dhan Chand, Dennis Underwood, Garo Armen, Arsen Arakelyan, Lilit Nersisyan, Hans Binder. Transcriptomic Maps of Colorectal Liver Metastasis: Machine Learning of Gene Activation Patterns and Epigenetic Trajectories in Support of Precision Medicine. Cancers. 2023. 15: 3835.
• B. Frost, M. Schmidt, B. Klein, H. Loeffler-Wirth, K. Krohn, T. Reidenbach, H. Binder, A. Stubenvoll, J. C. Simon, A. Saalbach, M. Kunz. Single-cell transcriptomics reveals prominent expression of IL-14, IL-18, and IL-32 in psoriasis. Eur J Immunol. 2023. e2250354.
• M. Helm, M. Schmidt, E. Del Duca, Y. Liu, L. S. Mortensen, J. Loui, Y. Zheng, H. Binder, E. Guttman-Yassky, G. Cotsarelis, J. C. Simon, R. A. Ferrer. Repurposing DPP4-Inhibition to Improve Hair Follicle Activation and Regeneration. J Invest Dermatol. 2023.

2022 (4)

• Hans Binder, Maria Schmidt, Lydia Hopp, Suren Davitavyan, Arsen Arakelyan, Henry Loeffler-Wirth. Integrated Multi-Omics Maps of Lower-Grade Gliomas. Cancers. 2022. 14:
• Henry Loeffler-Wirth, Lydia Hopp, Maria Schmidt, Roksana Zakharyan, Arsen Arakelyan, Hans Binder. The Transcriptome and Methylome of the Developing and Aging Brain and Their Relations to Gliomas and Psychological Disorders. Cells. 2022. 11: 362.
• Henry Loeffler-Wirth, Markus Kreuz, Maria Schmidt, German Ott, Reiner Siebert, Hans Binder. Classifying Germinal Center Derived Lymphomas—Navigate a Complex Transcriptional Landscape. Cancers. 2022. 14:
• Josefine Radke, Naveed Ishaque, Randi Koll, Zuguang Gu, Elisa Schumann, Lina Sieverling, Sebastian Uhrig, Daniel Hübschmann, Umut H. Toprak, Cristina López, Xavier Pastor Hostench, Simone Borgoni, Dilafruz Juraeva, Fabienne Pritsch, Nagarajan Paramasivam, Gnana Prakash Balasubramanian, Matthias Schlesner, Shashwat Sahay, Marc Weniger, Debora Pehl, Helena Radbruch, Anja Osterloh, Agnieszka Korfel, Martin Misch, Julia Onken, Katharina Faust, Peter Vajkoczy, Dag Moskopp, Yawen Wang, Andreas Jödicke, Lorenz Trümper, Ioannis Anagnostopoulos, Dido Lenze, Ralf Küppers, Michael Hummel, Clemens A. Schmitt, Otmar D. Wiestler, Stephan Wolf, Andreas Unterberg, Roland Eils, Christel Herold-Mende, Benedikt Brors, Reiner Siebert, Susanne Wagner, Andrea Haake, Julia Richter, Gesine Richter, Chris Lawerenz, Jürgen Eils, Jules Kerssemakers, Christina Jaeger-Schmidt, Ingrid Scholz, Anke K. Bergmann, Christoph Borst, Friederike Braulke, Birgit Burkhardt, Alexander Claviez, Martin Dreyling, Sonja Eberth, Hermann Einsele, Norbert Frickhofen, Siegfried Haas, Martin-Leo Hansmann, Dennis Karsch, Nicole Klepl, Michael Kneba, Jasmin Lisfeld, Luisa Mantovani-Löffler, Marius Rohde, German Ott, Christina Stadler, Peter Staib, Stephan Stilgenbauer, Thorsten Zenz, Dieter Kube, Wolfram Klapper, Ulrike Kostezka, Peter Möller, Andreas Rosenwald, Monika Szczepanowski, Ole Ammerpohl, Sietse M. Aukema, Vera Binder, Arndt Borkhardt, Jessica I. Hoell, Ellen Leich, Peter Lichter, Inga Nagel, Jordan Pischimariov, Bernhard Radlwimmer, Philip Rosenstiel, Markus Schilhabel, Stefan Schreiber, Inga Vater, Rabea Wagener, Stephan H. Bernhart, Hans Binder, Gero Doose, Steve Hoffmann, Lydia Hopp, others. The genomic and transcriptional landscape of primary central nervous system lymphoma. Nature communications. 2022. 13: 2558.

2021 (7)

• Hans Binder, Maria Schmidt, Henry Loeffler-Wirth, Lena Suenke Mortensen, Manfred Kunz. Melanoma Single-Cell Biology in Experimental and Clinical Settings. Journal of Clinical Medicine. 2021. 10: 506.
• Janik Böhnke, Sandra Pinkert, Maria Schmidt, Hans Binder, Nicole Christin Bilz, Matthias Jung, Uta Reibetanz, Antje Beling, Dan Rujescu, Claudia Claus. Coxsackievirus B3 Infection of Human iPSC Lines and Derived Primary Germ-Layer Cells Regarding Receptor Expression. International Journal of Molecular Sciences. 2021. 22: 1220.
• Maria Schmidt, Mamoona Arshad, Stephan H. Bernhart, Siras Hakobyan, Arsen Arakelyan, Henry Loeffler-Wirth, Hans Binder. The Evolving Faces of the SARS-CoV-2 Genome. Viruses. 2021. 13: 1764.
• Maria Schmidt, Lena Sünke Mortensen, Henry Loeffler-Wirth, Corinna Kosnopfel, Knut Krohn, Hans Binder, Manfred Kunz. Single-cell trajectories of melanoma cell resistance to targeted treatment. Cancer biology & medicine. 2021.
• M. Schmidt, L. S. Mortensen, H. Loeffler-Wirth, C. Kosnopfel, K. Krohn, H. Binder, M. Kunz. Single-cell trajectories of melanoma cell resistance to targeted treatment. Cancer Biol Med. 2021. 19: 56-73.
• E. Willscher, L. Hopp, M. Kreuz, M. Schmidt, S. Hakobyan, A. Arakelyan, H. Loeffler-Wirth, H. Binder, et al. High-Resolution Cartography of the Transcriptome and Methylome Landscapes of Diffuse Gliomas. Cancers (Basel). 2021. 13:
• Johannes Wolf, Edith Willscher, Henry Loeffler-Wirth, Maria Schmidt, Gunter Flemming, Marlen Zurek, Holm H. Uhlig, Norman Händel, Hans Binder. Deciphering the Transcriptomic Heterogeneity of Duodenal Coeliac Disease Biopsies. International Journal of Molecular Sciences. 2021. 22: 2551.

2020 (5)

• H. Loeffler-Wirth, M. Schmidt, H. Binder. Covid-19 Transmission Trajectories-Monitoring the Pandemic in the Worldwide Context. Viruses. 2020. 12:
• M. Nikoghosyan, M. Schmidt, K. Margaryan, H. Loeffler-Wirth, A. Arakelyan, H. Binder. SOMmelier—Intuitive Visualization of the Topology of Grapevine Genome Landscapes Using Artificial Neural Networks. MDPI Journals Genes. 2020. 11: 21.
• M. Schmidt, L. Hopp, A. Arakelyan, H. Kirsten, H. Loeffler-Wirth, H. Binder, et al. The Human Blood Transcriptome in a Large Population Cohort and Its Relation to Aging and Health. Front Big Data. 2020. 3: 548873.
• M. Schmidt, H. Loeffler-Wirth, H. Binder. Developmental scRNAseq Trajectories in Gene- and Cell-State Space-The Flatworm Example. Genes (Basel). 2020. 11:
• M. Schmidt, L. Hopp, A. Arakelyan, H. Kirsten, C. Engel, K. Wirkner, M. Loeffler, H. Loeffler-Wirth, H. Binder, et al. The Human Blood Transcriptome in a Large Population Cohort and Its Relation to Aging and Health. 2020.

MISCELLANEOUS