Dr. rer. nat Henry Löffler-Wirth

Dr. rer. nat Henry Löffler-Wirth
Tel: 0341 - 97 16696
E-Mail: wirth@izbi.uni-leipzig.de
Room: 326
Position: Junior Group Leader
Groups: Omics bioinformatics for health and systems biology, Algorithms for complex data in life sciences

Academic Career

  • 2002 - 2008  Chemnitz University of Technology Diploma in “Computer Science”, main course “Artificial Intelligence” Diploma thesis: “Modeling of a cellular automaton based on dendritic cells and application in pattern recognition.”
  • 2008 - 2011 Interdisciplinary Centre for Bioinformatics - IZBI, Leipzig UniversityHelmholtz centre for environmental research – UFZ, Leipzig PhD student, “HIGRADE”-scholarship holder (UFZ)
  • 2011 - 2012 Interdisciplinary Centre for Bioinformatics - IZBI, Leipzig University Leipzig Interdisciplinary Research Cluster of Genetic Factors, Clinical Phenotypes and Environment - LIFE, Leipzig University PhD student, research fellow PhD in “Computer Science”, subject “Bioinformatics” PhD thesis: “Analysis of large-scale molecular biological data using self-organizing maps.
  • 2012 - 2014 Interdisciplinary Centre for Bioinformatics - IZBI, Leipzig UniversityPostDoc, research fellow
  • since 2014 Leader of Junior Research Group ‘Algorithms for complex data in life sciences’

Scientific Interests


2017 (1)

  • K. Keysselt, T. Kreutzmann, K. Rother, C. Kerner, K. Krohn, J. Przybilla, P. Buske, H. Loffler-Wirth, M. Loeffler, J. Galle, G. Aust. Different in vivo and in vitro transformation of intestinal stem cells in mismatch repair deficiency. Oncogene. 2017. 36: 2750-2761.

2016 (4)

  • L. Rohani, C. Fabian, H. Holland, Y. Naaldijk, R. Dressel, H. Loeffler-Wirth, H. Binder, A. Arnold, A. Stolzing. Generation of human induced pluripotent stem cells using non-synthetic mRNA. Stem Cell Res. 2016. 16: 662-72.
  • H. Loeffler-Wirth, E. Willscher, P. Ahnert, K. Wirkner, C. Engel, M. Loeffler, H. Binder. Novel Anthropometry Based on 3D-Bodyscans Applied to a Large Population Based Cohort. PLoS One. 2016. 11: e0159887.
  • T. Gerber, E. Willscher, H. Loeffler-Wirth, L. Hopp, D. Schadendorf, M. Schartl, U. Anderegg, G. Camp, B. Treutlein, H. Binder, M. Kunz. Mapping heterogeneity in patient-derived melanoma cultures by single-cell RNA-seq. Oncotarget. 2016.
  • A. Arakelyan, L. Nersisyan, M. Pentrak, H. Loeffler-Wirth, H. Binder. Cartography of Pathway Signal Perturbations Identifies Distinct Molecular Pathomechanisms in Malignant and Chronic Lung Diseases. Front Genet. 2016. 7: 79.

2015 (8)

  • V. Kumar, J. E. Bouameur, J. Bar, R. H. Rice, H. T. Hornig-Do, D. R. Roop, N. Schwarz, S. Brodesser, S. Thiering, R. E. Leube, R. J. Wiesner, P. Vijayaraj, C. B. Brazel, S. Heller, H. Binder, H. Loeffler-Wirth, P. Seibel, T. M. Magin. A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity. J Cell Biol. 2015. 211: 1057-75.
  • H. Löffler-Wirth, M. Kalcher, H. Binder. oposSOM: R-package for high-dimensional portraying of genome-wide expression landscapes on bioconductor. Bioinformatics. 2015. 31: 3225-7.
  • M. Weller, R. G. Weber, E. Willscher, V. Riehmer, B. Hentschel, M. Kreuz, J. Felsberg, U. Beyer, H. Löffler-Wirth, K. Kaulich, J. P. Steinbach, C. Hartmann, D. Gramatzki, J. Schramm, M. Westphal, G. Schackert, M. Simon, T. Martens, J. Bostrom, C. Hagel, M. Sabel, D. Krex, J. C. Tonn, W. Wick, S. Noell, U. Schlegel, B. Radlwimmer, T. Pietsch, M. Löffler, A. von Deimling, H. Binder, G. Reifenberger. Molecular classification of diffuse cerebral WHO grade II/III gliomas using genome- and transcriptome-wide profiling improves stratification of prognostically distinct patient groups. Acta Neuropathol. 2015. 129: 679-93.
  • L. Hopp, E. Willscher, H. Löffler-Wirth, H. Binder. Function Shapes Content: DNA-Methylation Marker Genes and their Impact for Molecular Mechanisms of Glioma. Journal of Cancer Research Updates. 2015. 11/2015: 127-148.
  • L. Hopp, L. Nersisyan, H. Löffler-Wirth, A. Arakelyan, H. Binder. Epigenetic Heterogeneity of B-Cell Lymphoma: Chromatin Modifiers. Genes (Basel). 2015. 6: 1076-112.
  • H. Binder, H. Wirth. Analysis of Large-Scale OMIC Data Using Self Organizing Maps. In: Encyclopedia of Information Science and Technology, Third Edition, IGI Global 2015. 1642-1653. Ed: Khosrow-Pour Mehdi.
  • L. Hopp, H. Löffler-Wirth, H. Binder. Epigenetic Heterogeneity of B-Cell Lymphoma: DNA Methylation, Gene Expression and Chromatin States. Genes (Basel). 2015. 6: 812-40.
  • H. Binder, L. Hopp, K. Lembcke, H. Wirth. Personalized disease phenotypes from massive omics data. In: Big Data Analytics in Bioinformatics and Healthcare , IGI Global 2015. 359-378. Ed: Wang Baoying and Li Ruowang and Perrizo William.

2014 (10)

  • L. Nersisyan, H. Loeffler-Wirth, A. Arakelyan, H. Binder. Gene Set- and Pathway- Centered Knowledge Discovery Assigns Transcriptional Activation Patterns in Brain, Blood, and Colon Cancer: A Bioinformatics Perspective. International Journal of Knowledge Discovery in Bioinformatics (IJKDB). 2014. 4: 46-69.
  • G. Reifenberger, R. G. Weber, V. Riehmer, K. Kaulich, E. Willscher, H. Wirth, J. Gietzelt, B. Hentschel, M. Westphal, M. Simon, G. Schackert, J. Schramm, J. Matschke, M. C. Sabel, D. Gramatzki, J. Felsberg, C. Hartmann, J. P. Steinbach, U. Schlegel, W. Wick, B. Radlwimmer, T. Pietsch, J. C. Tonn, A. von Deimling, H. Binder, M. Weller, M. Loeffler. Molecular characterization of long-term survivors of glioblastoma using genome- and transcriptome-wide profiling. Int J Cancer. 2014.
  • H. Wirth, M. V. Cakir, L. Hopp, H. Binder. Analysis of MicroRNA Expression Using Machine Learning. Methods Mol Biol. 2014. 1107: 257-78.
  • H. Wirth, M.V. Çakir, L. Hopp, H. Binder. Analysis of MicroRNA Expression Using Machine Learning. In: miRNomics: MicroRNA Biology and Computational Analysis, Humana Press 2014. 1107: 257-278. Ed: Malik Yousef and Jens Allmer.
  • P. Charbord, C. Pouget, H. Binder, F. Dumont, G. Stik, P. Levy, F. Allain, C. Marchal, J. Richter, B. Uzan, F. Pflumio, F. Letourneur, H. Wirth, E. Dzierzak, D. Traver, T. Jaffredo, C. Durand. A systems biology approach for defining the molecular framework of the hematopoietic stem cell niche. Cell Stem Cell. 2014. 15: 376-91.
  • Mehmet Volkan Çakir, Henry Wirth, Lydia Hopp, Hans Binder. MicroRNA Expression Landscapes in Stem Cells, Tissues, and Cancer. In: miRNomics: MicroRNA Biology and Computational Analysis, Humana Press 2014. 1107: 279-302. Ed: Malik Yousef and Jens Allmer.
  • H. Binder, H. Wirth, A. Arakelyan, K. Lembcke, E. Tiys, V. Ivanisenko, N. Kolchanov, A. Kononikhin, I. Popov, E. Nikolaev, L. Pastushkova, I. Larina. Time-course human urine proteomics in space-flight simulation experiments. BMC Genomics. 2014. 15: S2.
  • M. V. Cakir, H. Binder, H. Wirth. Profiling of Genetic Switches using Boolean Implications in Expression Data. J Integr Bioinform. 2014. 11: 246.
  • M. V. Cakir, H. Wirth, L. Hopp, H. Binder. MicroRNA Expression Landscapes in Stem Cells, Tissues, and Cancer. Methods Mol Biol. 2014. 1107: 279-302.
  • A. Arakelyan, L. Nersisyan, H. Wirth, H. Binder. Mining common pathway deregulation profiles in lung diseases. European Respiratory Journal. 2014. 44:

2013 (4)

  • H. Wirth. Analyse molekularbiologischer Daten mittels Self-organizing Maps. In: Ausgezeichnete Informatikdissertationen Teil: 2012, Hölldobler, S. Gesellschaft für Informatik e.V., Bonn 2013. Lecture Notes in Informatics D-13: 291-300. Ed: GI-Edition.
  • A. Oberbach, N. Jehmlich, N. Schlichting, M. Heinrich, S. Lehmann, H. Wirth, H. Till, J. U. Stolzenburg, U. Volker, V. Adams, J. Neuhaus. Molecular fingerprint of high fat diet induced urinary bladder metabolic dysfunction in a rat model. PLoS One. 2013. 8: e66636.
  • L. Hopp, H. Wirth, M. Fasold, H. Binder. Portraying the expression landscapes of cancer subtypes: a glioblastoma multiforme and prostate cancer case study. Systems Biomedicine. 2013. 1:
  • L. Hopp, K. Lembcke, H. Binder, H. Wirth. Portraying the Expression Landscapes of B-CellLymphoma-Intuitive Detection of Outlier Samples and of Molecular Subtypes. Biology. 2013. 2: 1411-1437.

2012 (4)

  • H. Wirth, M. von Bergen, J. Murugaiyan, U. Rosler, T. Stokowy, H. Binder. MALDI-typing of infectious algae of the genus Prototheca using SOM portraits. J Microbiol Methods. 2012. 88: 83-97.
  • H. Wirth, M. von Bergen, H. Binder. Mining SOM expression portraits: feature selection and integrating concepts of molecular function. BioData Min. 2012. 5: 18.
  • L. Steiner, L. Hopp, H. Wirth, J. Galle, H. Binder, S. J. Prohaska, T. Rohlf. A global genome segmentation method for exploration of epigenetic patterns. PLoS One. 2012. 7: e46811.
  • A. Arnold, Y.M. Naaldijk, C. Fabian, H. Wirth, H. Binder, G. Nikkhah, L. Armstrong, A. Stolzing. Reprogramming of Human Huntington Fibroblasts Using mRNA. ISRN Cell Biology. 2012. 2012: 12.

2011 (5)

  • H. Wirth, M. von Bergen, J. Murugaiyan, U. Rosler, T. Stokowy, H. Binder. MALDI-typing of infectious algae of the genus Prototheca using SOM portraits. J Microbiol Methods. 2011. 88: 83-97.
  • H. Wirth, M. Löffler, M. von Bergen, H. Binder. Expression cartography of human tissues using self organizing maps. BMC Bioinformatics. 2011. 12: 306.
  • A. Oberbach, M. Blüher, H. Wirth, H. Till, P. Kovacs, Y. Kullnick, N. Schlichting, J. M. Tomm, U. Rolle-Kampczyk, J. Murugaiyan, H. Binder, A. Dietrich, M. von Bergen. Combined proteomic and metabolomic profiling of serum reveals association of the complement system with obesity and identifies novel markers of body fat mass changes. J Proteome Res. 2011. 10: 4769-88.
  • N. Morbt, J. Tomm, R. Feltens, I. Mogel, S. Kalkhof, K. Murugesan, H. Wirth, C. Vogt, H. Binder, I. Lehmann, M. von Bergen. Chlorinated benzenes cause concomitantly oxidative stress and induction of apoptotic markers in lung epithelial cells (A549) at nonacute toxic concentrations. J Proteome Res. 2011. 10: 363-78.
  • H. Binder, M. Fasold, L. Hopp, V. Cakir, M. von Bergen, H. Wirth. Genomic and molecular Phenotypic Portraits - Exploring The "Omes" With Individual Resolution. In: 6th International Symposium on Health Informatics and Bioinformatics (HIBIT) 2011. 115-122. Ed: IEEE Explore.

2010 (1)

  • H. Binder, H. Wirth, J. Galle. Gene expression density profiles characterize modes of genomic regulation: theory and experiment. J Biotechnol. 2010. 149: 98-114.

2009 (1)

  • M.v. Bergen, A. Eidner, F. Schmidt, J. Murugaiyan, H. Wirth, H. Binder, T. Maier, U. Roesler. Identification of harmless and pathogenic algae of the genus Prototheca by MALDI-MS. PROTEOMICS - CLINICAL APPLICATIONS. 2009. 3: 774-784.

2007 (1)

  • D. Voigt, H. Wirth, W. Dilger. A Computational Model for the Cognitive Immune System Theory Based on Learning Classifier Systems. 2007. 264-275.


  • June 2010 (1 week)Lipari School on Bioinformatics and Computational Biology, Lipari, Italy, Summer School: “Statistical and Machine Learning Methods in Computational Biology”
  • February 2011 Australian National University - ANU, Canberra, Australia, Research stay
  • since 2016 Hindawi ‘Advances in Bioinformatics’Member of Editorial Board