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Outlook: A Concept for a Cooperative Imaging and Image Analysis Platform
Ulf-Dietrich Braumann, Jens-Peer Kuska, Markus Löffler
Interdisciplinary Centre for Bioinformatics
University of Leipzig
Medical Faculty and life science related institutions within the University of Leipzig
Background: Today’s biomedical research heavily relies on digital imaging methods providing lots of excellent new possibilities for structural and functional analyses of cells and tissues. Many techniques have just recently experienced a significant technological breakthrough that offers new opportunities for cell and tissue imaging in situ but also raises new challenges to biologists, who must adapt to a rapidly evolving environment, and to computer scientists, who are required to develop new methods and tools of advanced multi-dimensional and cross-technology image analysis and management. These techniques include but are not restricted to confocal laser scanning microscopy, infrared and Raman imaging, multi-photon confocal microscopy, scanning acoustic microscopy, microscopic magnetic resonance imaging, positron emission tomography, as well as conventional transmitted light microscopy. While some methods are quite universal, others are very specific in their applications.
The understanding of cell biological processes needs a monitoring of the biochemical processes as well as a monitoring of the morphological changes in the cell and tissue. Image processing provides the only possibility to quantify e.g. morphological changes and certain functional effects. This regards, among others, the volume grow of tissues and organs as well as the analysis of cell collectives requiring different imaging techniques on various scales. In general, cross-technology analyses and assessments are indispensable. This demands a comprehensive set of image processing tools for registration, volume data processing, pattern and shape recognition, segmentation etc.
Own Technological Expertise: The image processing group at IZBI provides methods for the following areas:
Own Related Work: The image processing group at IZBI is involved in research projects on the following areas:
Image Analysis Examples from Ongoing Work: