Interdisciplinary Centre
for Bioinformatics

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IZBI

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Curriculum Bioinformatics

Systems Biology

• Integrated cell and tissue models
• Analyses and modelling of regulatory processes on the molecular level
• Methods of functional characterisation of cells
• Integrative mathematical modelling approaches
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• Conferences
  • Conferences 2006
  • Conferences 2002-2005
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Contact

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Projects

• Databases and Data Integration
  • Data Warehouse for Gene Expression Analysis
  • GenMapper
  • BioFuice
  • MediGRID
• Tissue Organisation
  • 3D-Reconstruction and Quantification of Tumour Invasion
  • Delimitation of squamous cell cervical carcinoma
  • Outlook: A Concept for a Cooperative Imaging and Image Analysis Platform
  • Individual Cell-based Models of Tumor-Environment Interactions: Multiple Effects of CD97 on Tumor Invasion
  • Outlook: Model of human and sheep MSC self-organization
  • Deregulated proliferation and apoptosis on the growth dynamics of epithelial cell populations
• Multicellular Systems
  • The emergence of tissue in evolution: Lessons from Trichoplax adhaerens
  • Modelling the growth of in-vitro tumor spheroids
  • Coarse graining in simulated growing cell populations
  • Classification of the growth dynamics of cell populations in vitro
  • Computational modelling of the spatial-temporal organization during liver regeneration
  • Growth optimization of MDCK-cells on Microcarriers
• Signal Transduction and Gene Expression
  • Sequence-specific hybridization of GeneChip microarrays
  • Search for functional gene expression signatures – some efficient computer programs
  • Multivariate procedures to increase power of microarray-based gene expression
  • Development of a Matrix CGH analysis pipeline
  • Meta-Analysis of Microarray Data
  • Gene expression analysis of autonomously functioning thyroid nodules (AFTNs) and cold thyroid nodules (CTNs)
  • Clinical Medicine and Molecular Genetics: Data Management and Analysis
• Genetic Evolution
  • Methods for Inference of Metazoan Phylogeny
  • RNA Morphology Using Constraint-Directed Folding
  • Transcription Factor Target Detection in Comparative Genomics
  • Non-protein coding RNA – computational RNomics
  • RNA-Based Gene Phylogeny
  • Simulations of Genome Evolution
  • Codaln - Nucleic Acid Sequence Alignments of Partly Coding Regions